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Development of Automatic Multi-channel SPR Detecting Instrument

Author: LiQiLin
Tutor: WangXiaoPing；LiuYuLing
School: Zhejiang University
Course: Optical Engineering
Keywords: SPR Sampling system Injection system Multi- channel SPR sensor
CLC: TP216
Type: Master's thesis
Year: 2011
Downloads: 100
Quote: 0
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Abstract


SPR sensing technology and traditional means of detection , with no need to mark the sample , required less sample , real-time dynamic detection , high sensitivity , in the field of medical diagnostics, environmental monitoring , biotechnology , pharmaceutical development and food safety inspection has a broad application prospects . The SPR instrument large commercialized are oriented laboratory analysis of large-scale precision instruments, these instruments in order to get a better measurement accuracy and automated detection capability , the optical system , automatic injector system is more complex, there are large in size , cost high disadvantage of limiting the promotion of the use of . Therefore, the development of a fully automated , high sensitivity , low-cost the SPR detection equipment , will undoubtedly have a huge social and economic benefits . This article describes an independent research and development based on surface plasmon resonance (SPR) principle fully automated multi - channel SPR detection equipment . The detection instrument consists of a sampling system , sample injection system , the SPR sensor and control circuit of several parts . The sampling system includes a vertically movable sample injection needle , and 16 - well sample tray, 15 kinds of the sample measurement and the injection needle is automatically cleaned . Sample injection system consists of two precision syringe pump and an electric rotary valve to ensure automatic injection process in the sample , there is always a solution flows through the SPR sensor surface . Throughout the sample measurement process by the sampling system , the injection system and the control circuit together to complete , the use can effectively prevent the injection method of the isolation of the air buffer or regeneration liquid is mixed with the sample , reducing the measurement error of the instrument . The sensor is the core of the entire instrument , using the laboratory 's own design of a dual-channel SPR sensor . The control circuit includes : C8051F020 as the core of the MCU control unit to control the autosampler system of pumps, valves ; a USB2.0 interface circuit CY7C68013 as the core , to achieve two-way communication with the PC , the data will be collected in real time uploaded to a PC for further analysis and processing . By experiments and data analysis of the detection of the concentration of sucrose solution prove apparatus have a higher resolution , sensitivity, and good reproducibility .

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CLC: > Industrial Technology > Automation technology,computer technology > Automation technology and equipment > Automation components,parts > Automatic testing equipment,instruments
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