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Novel ferrocenyl of 1,3,4 - thiadiazole compound synthesis and biological activity test

Author: YuanQing
Tutor: GouXiaoFeng
School: Northwestern University
Course: Organic Chemistry
Keywords: Ferrocene amines 1,3,4 - thiadiazole derivatives Synthesis Auxin activity
CLC: O627.81
Type: Master's thesis
Year: 2011
Downloads: 53
Quote: 0
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Abstract


In recent years , the ferrocene derivatives and 1,3,4 - thiadiazole heterocyclic compounds with its unique nature and higher value by more and more attention of scientists . Reported the ferrocene derivatives and 1,3,4 - thiadiazole compounds , synthetic methods and application , but the ferrocene groups introduced into 1,3,4 - thiadiazole compounds reported less . Accordingly, in order to make the kind of the compound 1,3,4 - thiadiazol more perfect , find a heterocyclic compound having biological activity containing ferrocenyl 1,3,4 - thiadiazol , we synthesized a series of differently substituted the group of new compounds , and such derivatives of the plant growth regulating activity test . Screening , we expect to get efficient , low toxicity and high selectivity of the new pesticide . This article by formyloxy ferrocene and 5 - substituted -2 - amino - 1 ,3,4 - thiadiazole was synthesized by the reaction of 20 kinds of Schiff base , and potassium borohydride reduction to give the amine compound of the 20 kinds of ferrocene , through the use of nuclear magnetic resonance spectroscopy, infrared spectroscopy, melting point, elemental analysis , and other means to characterize the structure of the target compounds , the experimental results show that the target compounds is consistent with the initial prediction structure . The final target compounds for biological activity tests . The test results show that : the vast majority of compounds having a good auxin activity , and some compounds have good cytokinin activity .

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CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Elements in organic compounds > Ⅷ of group elements, organic compounds > Iron organic compounds
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