|
Objective To investigate the triple negative breast cancer (TNBC) clinical and pathological features, and further comparative analysis of triple negative breast cancer and non-triple negative breast cancer (non-TNBC) ultrasound performance characteristics and differences. To enhancing awareness of TNBC ultrasound doctors to improve the level of ultrasonic diagnosis of breast cancer. Methods January 2007 - February 2010, First Affiliated Hospital of Guangxi Medical University hospital surgical gastrointestinal glands in female patients. Preoperative bilateral breast and axillary ultrasound examination, ultrasound findings include recording tumor size, spiculation, posterior echo, microcalcifications, blood flow; postoperative pathological diagnosis of breast cancer. All patients underwent postoperative specimens examined by immunohistochemistry pathological predictors of estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor -2 (HER-2) expression, recording the incidence age, menopausal conditions, axillary lymph node metastasis, clinical stage, histological type, P53 expression status and other clinical and pathological features. The inclusion criteria were divided into two groups of TNBC and non-TNBC, after ultrasound and its clinical and pathological features were analyzed statistically. Results ① met the inclusion criteria for patients with complete data of 318 cases, of which there are 52 cases of TNBC, accounting for 16.35%. ② TNBC group showed pathological axillary lymph node metastasis rate was 55.77%, higher than the non-TNBC group (P lt; 0.05), and the incidence of age, menopause, clinical stage, histological type and P53 expression status and non-TNBC, the difference not statistically significant (P gt; 0.05). ③ 318 patients with breast cancer in two cases ultrasound did not show lesions, more than 316 cases of breast cancer in ultrasound showed tumor diameter gt; 2cm accounted for 60.76% (192/316); tumor edge with burr accounted for 40.82 percent levy (129/316); mass posterior echo attenuation by 24.05% (76/316); mass interior with microcalcifications were 42.72% (135/316); mass internal flow grade Ⅱ ~ Ⅲ were 65.82% (208/316). ④ ultrasound showed, TNBC group diagnosis of solid mass, determined the nature of the proportion of the number of cases was 23.08%, compared with non-TNBC, the difference was statistically significant (P lt; 0.05) ⑤ TNBC group tumor edge burr Zheng, internal microcalcifications and CDFI flow grade of grade Ⅱ ~ Ⅲ proportion of the number of cases were 23.08%, 28.85%, 51.92%, lower than the non-TNBC group, 44.32%, 45.45%, 68.56% (P lt; 0.05); TNBC group, tumor diameter gt; 2cm and no lumps posterior echo attenuation slightly higher proportion of patients, but with non-TNBC group, the difference was not statistically significant (P gt; 0.05). Conclusion ① TNBC this group accounted for about 16% of the total number of breast cancer; ② TNBC compared with non-TNBC, lymph node metastasis rate is higher; ③ sonographic manifestations, some TNBC compared with non-TNBC, the lack of typical breast Cancer ultrasonography (such as spiculation, microcalcifications, rich blood flow, etc.). Difficulty with benign masses were identified in the ultrasound diagnosis should pay attention to.
|