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Objective: To systematically evaluate methotrexate single dose and multiple dose intramuscular treatment of ectopic pregnancy. Of The the Cochrane libraly: computer retrieval (1992-2010) the CNKI, VIP, PubMed, Medline, Wanfang. The manual searches related magazines (1992-2010). Into all methotrexate single intramuscular injection and multiple intramuscular controlled clinical trials of the effectiveness comparison of the treatment of ectopic pregnancy (Controlled Clinical Trials, CCTs), Cochrane systematic review by two researchers independently included studies extract the relevant data and evaluate the quality of the included studies. Meta-analysis Revman5.0.25 extract data, OR (odds ratio) and the 95% CI (confidence interval). System evaluation are: the success rate, failure rate, the gastrointestinal reaction rate, oral mucosal damage rate, rate of bone marrow suppression, liver dysfunction rate, abdominal pain, incidence, and repeated drug use rate. Literature included the test for heterogeneity heterogeneity by using fixed effect model merger analysis; heterogeneity, the analysis of the heterogeneity of the reasons for processing using sensitivity analysis or random effects model. Results: included in the controlled clinical trials for treatment of ectopic pregnancy validity of comparing single and multiple doses of intramuscular 11, a total of 1096 cases. Included all studies, ultrasound pregnancy mass diameter ≤ 5cm, serum β-HCG lt; 6000U / L: the success rate of the single dose group [OR = 2.04, 95% CI (1.46,2.84), P lt; 0.0001] compared with several high-dose group, the failure rate [OR = 0.39, 95% CI (0.25,0.61), P lt; 0.0001] than multiple low-dose group; two groups in the rate of gastrointestinal reactions [OR = 0.88 When ultrasound pregnancy mass diameter ≤ 4cm, blood β-HCG lt; 2000U / L subgroup comparison: the single dose group in the success rate [OR = 1.34, 95% CI (0.79,2.28), P = 0.28]. ,Conclusion: Ultrasound ectopic pregnancy mass diameter ≤ 5cm, blood β-HCG lt; 6000U / L, single intramuscular injection of methotrexate treatment of ectopic pregnancy effective than multiple intramuscular; ultrasound pregnancy mass diameter ≤ 4cm, blood β-HCG lt; 2000U / L, single intramuscular injection of methotrexate and multiple intramuscular treatment of ectopic pregnancy success rate, failure rate, drug side effects and repeated drug use rate was no correlation; Description methotrexate single intramuscular injection of multiple effects of intramuscular treatment of ectopic pregnancy with pre-treatment serum β-HCG levels are closely related to the correlation with ultrasound pregnancy mass diameter.
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