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Different doses of atorvastatin prevention of contrast -induced nephropathy

Author: QiChunLei
Tutor: ChenHuanZhen
School: Shanxi Medical
Course: Internal Medicine
Keywords: Statins Contrast agent Renal injury Acute
CLC: R692.9
Type: Master's thesis
Year: 2011
Downloads: 38
Quote: 0
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Abstract


Objective: To study different doses of atorvastatin statin calcium of contrast agent-induced renal damage in the short-term improvement, Statistics by coronary interventional treatment of patients (coronary angiography and stent implantation patients) the incidence of CIN, and to explore the pathogenesis of CIN . METHODS: June 2009 -2010 in December at the First Hospital of Shanxi Medical hospitalization have coronary angiography and stent implantation indications 143 patients as research subjects, male 96 cases, female 47 cases, with an average age 59.2 ± 9.6 years; average weight of 74.5 ± 11.6 (kg). Table hair divided into group A, group B and group C patients selected randomly. Group A = 40mg group, 52 cases; group B = 20mg 51 cases; and C groups = 10mg 40 cases. Selected patients with preoperative and postoperative were given atorvastatin calcium tablets orally at bedtime, after one week to decide whether to continue taking or increase atorvastatin calcium dose based on the results of the clinical examination. Preoperative and postoperative 24h, 72h fasting drawing blood from patients measured serum creatinine (Scr), blood urea nitrogen (BUN), serum cystatin C (Cys-c), and blood β 2 - microspheres protein (β 2 -MG), high-sensitivity C-reactive protein (hs-CRP), and specimens from the same urine, measured α 1 - micro globulin (α < sub> 1 -MG) and urinary albumin (mALB), change the situation. Endogenous creatinine clearance rate (Ccr) calculated by the Cockcroft-Gault formula. Results: General clinical data of patients enrolled patients before surgery statistics showed no significant difference. Preoperative detection of biochemical indicators of difference was not statistically significant (P> 0.05). The three groups of patients after 24 h, 72h Scr, BUN difference was not statistically significant. A group of patients with postoperative 24h Ccr slightly higher than that of group C and group B (P> 0.05); The postoperative 72hCcr significantly higher than that in group C (P <0.05); than in group B (P> 0.05); A group of Cys-c postoperative 24h, 72 h Cys-C was significantly lower than in group C, slightly lower than in group B (P <0.05). Group A β 2 -MG postoperative 24h, 72 h was significantly lower than in group C and group B (P <0.05); the group Hs-crp A postoperative 24h, 72 h surgery was significantly lower than that in group C (P <0.05), slightly lower than in group B (P> 0.05); A group α to 1 -MG postoperative 24h, 72 h after surgery significantly lower than that in group C (P <0.05), slightly lower than that in group B (P> 0.05); the group A urine mALB 24h after significantly lower than that in group C (P <0.05), slightly lower than in group B (P> 0.05), postoperative 72h the three groups was not significantly different (P> 0.05); B group of Cys-c after 24h, 72 h Cys-C was significantly lower than that in group C (P <0.05); group B β 2 -MG postoperative 24h, 72 h Cys-c slightly lower than the C group (P> 0.05); the group Hs-crp B postoperative 24h, 72 h Cys-c was significantly lower than that in group C (P <0.05); group B α 1 -MG Hs after-crp 24h 72 hCys,-c significantly lower than that in group C (P <0.05); the B group urine mALB 24h after surgery was significantly lower than that in group C (P <0.05), no significant difference after surgery 72 hB and C groups . Conclusion: surgery (coronary angiography and stent implantation) underwent coronary intervention patients taking atorvastatin than taking 40mg 20mg 10mg can reduce the body's inflammatory response, reduced glomerular acute renal tubular injury, improve glomerular filtration rate to prevent the occurrence of CIN; coronary intervention the clinics surgery in patients with CIN incidence of 8.3%.

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CLC: > Medicine, health > Surgery > Urology ( urinary and reproductive system diseases) > Kidney disease > Other diseases
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