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Objective To investigate the preoperative pain sensitivity and propofol phenol target-controlled sedation and reach a certain depth of sedation, respiratory cycle inhibition of whether there is a correlation, and provide a reference for the clinical propofol target-controlled sedation personalized medicine and anesthesia safety. Methods ASA Ⅰ ~ Ⅱ, aged 20 to 60 years old, 60 cases of female patients underwent endotracheal intubation general anesthesia, the day before the surgery afternoon electricity tester stimulus pain threshold determination of the patient's pain sensitivity (pain threshold and pain tolerance threshold) and assess the patient preoperative psychological status (Zung's Self-Rating Depression Scale and Zung's anxiety self-rating scale). Measure the following items, open upper extremity venous access patient into the operating room, the infusion of Ringer's lactate 10ml/kg losers (30 min), followed by 10ml / (kg.h) speed to maintain the infusion repose 5min the basis of values: systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), pulse oximetry (SpO2) and heart rate (HR) after stepwise target-controlled infusion of propofol sedation, C propofol effect-the initial concentration of 1.0μg/ml (effect-concentration target concentration) began to be plasma concentration target effect concentration equilibrium to maintain 3min, following 0.2μg/ml concentration gradient increments every 20s line sedation score (OAA / S), until the OAA / S sedation score to reach 100 points immediately after the mask pressure oxygen, while the target-controlled injection the remifentanil 4ng/ml (effect-site concentration) given vecuronium 0.1mg / kg, 3min tracheal intubation. Target-controlled infusion of propofol during induction (to the muscle relaxant), so spontaneous breathing air, by observing the changes in blood pressure, heart rate and blood oxygen saturation to determine the degree of suppression of propofol on patient breathing and circulation. During this period if the patient SpO2 lt; 90% which is giving the oxygen mask and assisted breathing. Record OAA / S score of 3 points and timeshare corresponding propofol effect-site concentration as well as the patient's blood pressure, heart rate, blood oxygen saturation. Measurement data were presented as mean ± standard deviation (x ± s), application SPSS13.0 statistical package for statistical analysis. Preoperative anxiety scores, depression scores, pain threshold and pain tolerance threshold as the independent variable, OAA / S score 3 points and a timeshare corresponding propofol effect-site concentration, MAP, HR, the SpO 2 < / sub> difference with the basic values ??of the dependent variable, and Pearson correlation analysis inspection preoperative anxiety score, depression score, pain threshold, pain tolerance threshold OAA / S score 3 points, a timeshare corresponding effect-site concentration the relationship; pain threshold, pain tolerance threshold and OAA / S score 3 points, a timeshare MAP, HR, the SpO 2 and basic value of the difference between the relationship. Significant variable regression equation with indicators derived using stepwise multiple linear regression analysis. P lt; 0.05 was considered statistically significant. ⒈ patient's mental state (anxiety score, depression score) and preoperative pain threshold, pain tolerance threshold was not related to sex (P gt; 0.05); preoperative pain tolerance threshold and OAA / S 3, a time-sharing required propofol effect-site concentration was positively correlated (r = 0.664, P lt; 0.05; r = 0.667, P lt; 0.05); patients with preoperative pain threshold OAA / S score of 3 points, a time-sharing propofol effect-site concentration required resistance (r = -0.117, P gt; 0.05; r = -0.138, P gt; 0.05); preoperative pain tolerance threshold OAA / S 3, 1 of the timesharing MAP, HR, the SpO 2 and basic values ??difference was positively correlated; preoperative pain threshold OAA / S sub 1 timeshare MAP, HR, SpO 2 with the underlying value of the difference between no correlation; surgery pain tolerance threshold as the regression equation, the resulting regression equation: y (OAA/S3 timeshare propofol effect-calculated) = 0.36 x (pain tolerance threshold) 1.66; y (OAA/S1 timeshare propofol effect-calculated value) = 0.38x (pain tolerance threshold) 1.95. y (OAA/S3 timeshare the MAP and basic value difference) = 7.77x (pain tolerance threshold) -10.60; y (OAA/S1 timeshare MAP and the basis of the value of the difference) = 7.96x (pain tolerance threshold) -4.17 ; y (OAA/S3 timeshare HR and the basis of the value of the difference) = 4.08x (pain tolerance threshold) -8.55; y (OAA/S1 the timeshare HR and the basis of the value of the difference) = 5.10x (pain tolerance threshold) -9.24 ; y (OAA/S3 timeshare the SpO 2 and the underlying value of the difference) = 1.73x (pain tolerance threshold) -1.78; pain tolerance threshold as the SpO 2 difference The regression equation is: y (OAA/S1 timeshare the SpO 2 and the basis of the value of the difference) = 1.83x (pain tolerance threshold) 1.38 Conclusion 1. preoperative pain tolerance threshold and target-controlled infusion of propofol the phenol sedative effect-site concentration required was positively related to the higher preoperative pain tolerance threshold, the higher the concentration of target-controlled infusion of propofol sedative effect compartment; 2. preoperative pain tolerance threshold and target-controlled infusion propionate Propofol sedation was positively correlated with the degree of inhibition of the respiratory cycle, that is, the higher the preoperative pain tolerance threshold, target-controlled propofol sedation more obvious degree of inhibition of the respiratory cycle.
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