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Effects of Three Components of PM2.5 on Renal Artery to Vasoactives and Serum Level of NOS/NO

Author: SunMeng
Tutor: LvJiYuan
School: Shanxi Medical
Course: Department of Cardiology
Keywords: PM2.5 Renal arterial rings Shrink Diastolic NOS / NO
CLC: R54
Type: Master's thesis
Year: 2011
Downloads: 31
Quote: 0
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Abstract


Objective: In this study, observed PM2.5 water-soluble ingredients, the ingredients of the fat-soluble and water-soluble and fat soluble mixed components of the rat isolated renal artery vascular ring resting tension of potassium chloride (KCL) and thromboxane (U46619 ) constricts blood vessels, acetylcholine (Ach) and sodium nitroprusside (SNP) diastolic the vasoactive impact on renal artery contraction explore PM2.5 water-soluble ingredients and organic ingredients - the impact of the relaxation response and its possible mechanism. The Methods: distilled water or organic solvents were extracted PM2.5 water-soluble ingredients and fat soluble ingredients were injected via the tail vein of rats PM2.5 water soluble components, lipid-soluble ingredients and mixing ingredients, continuous exposure 10d. Tension the DMT and PowerLab system records the rat renal arterial rings, serological testing in rats NOS / NO system changes. Observation: (1) compared to the control group of PM2.5 exposure group renal arterial rings to KCl and U46619-induced contraction reaction change; (2) compared to the control group of PM2.5 exposure group renal arterial rings the relaxation response to acetylcholine (Ach) and sodium nitroprusside (SNP) differences; (3) in comparison with the control group, serum NO of PM2.5 exposure group, Ang II eNOS content and serum iNOS activity changes. Results: (1) compared with the control group of PM2.5 exposure groups to strengthen the contractile response to KCl and U46619 caused renal arterial rings, but no statistical significance (P gt; 0.05). (2) compared with the control group, PM2.5 exposure groups were weakened acetylcholine (ACH) relaxation of renal arterial rings (P lt; 0.05). (3) compared to the control group to weakened sodium nitroprusside (SNP) of PM2.5 exposure groups affect the renal artery rings of rats, no statistical significance (P gt; 0.05). (4) Compared with the control group, serum NO content of PM2.5 exposure group were significantly higher (P lt; 0.05); blending component exposed groups serum eNOS content significantly reduce (P gt; 0.05), while the water-soluble ingredients group no significant difference; different experimental serum iNOS activity was significantly higher (P lt; 0.05) and fat soluble ingredients group; different experimental serum concentration of Ang Ⅱ were significantly lower (P lt; 0.05). Conclusions: (1) PM2.5 water soluble components, fat soluble ingredients and mixing ingredients in the body exposed to strengthen KCl and U46619 no significant difference in the contractile response of the renal arteries ring. (2) PM2.5 water-soluble ingredients, fat-soluble ingredients and mixing ingredients in the body exposed to diminished renal vascular ring relaxation effect of acetylcholine (ACH), this effect may be related to the to PM2.5 injury endothelial function. (3) PM2.5 water soluble components, fat soluble ingredients and mixing ingredients in the body exposed to the serum concentration of NO were significantly increased. () Of PM2.5 mixed ingredients exposed groups serum was significantly decreased eNOS. (5) PM2.5 water-soluble ingredients, fat-soluble ingredients and mixing ingredients in the body exposed to serum iNOS activity were significant increased. (6) PM2.5 water soluble components, fat soluble ingredients and mixing ingredients in the body exposed to the serum concentration of Ang Ⅱ were significantly decreased. (7) of PM2.5 exposure group is the role of the blood vessels may be the role may PM2.5 injured endothelial function and vascular endothelial NOS / NO system expression abnormalities

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CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease
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