Dissertation > Excellent graduate degree dissertation topics show

Sterile Isolating Device Research and Its CFD Simulation

Author: WangHuaPeng
Tutor: HeGuoGeng；NiuJinBo
School: Huazhong University of Science and Technology
Course: Power Engineering
Keywords: Isolating device Cleanliness degree Air flow organization Numerical simulation of CFD
CLC: R197.39
Type: Master's thesis
Year: 2011
Downloads: 20
Quote: 0
Read: Download Dissertation

Abstract


Drugs are special products used for prevention, treatment of disease, recovery and regulation the body functions. The use of them is directly related to the efficacy and people’health. However, in the manufacturing process, some of the drugs may be subject to microbial contamination or cross-contaminated. As a result, they may become harmful or even life-threatening to people.Years of practice and studies at home and abroad have shown that contamination or cross-contaminated of drugs mainly because of unqualified production environment, especially the factor of human beings. In order to avoid contamination or cross-contaminated of drugs, it is quite necessary to take effective measures to ensure that the drug production environment is highly clean. Isolating device installed in pharmaceutical equipment can effectively isolate the man from the pharmaceutical environment.This paper reviews the features and requirements of the pharmaceutical environment, introduces the classification and features of sterile isolators, points out the principles of achieving cleanness. By comparing isolators and conventional clean rooms, this paper finds the former superior to the latter. Besides, The modes of supply air and return air and factors of internal air flow organization are also analyzed in this paper. And on this basis, this paper gives some effective suggestions on pressure control.Taking Restrictive Access Barrier Systems (RABS) as an example, this paper describes the process of using Computational Fluid Dynamics (CFD) to authenticate and optimize the Preliminary design. By adopting Steady incompressible navier-stokes Renault time-averaged equation and k~εturbulent flow model, numerical simulation of the air flow organization in isolator in the preliminary design was carried out. What the numerical simulation revealed are as follow: Velocity distribution didn’t meet the requirements, Streamline shifted apparently, and there was a circulation zones. Therefore, return air form is adjusted. The second numerical simulation of air flow suggests that the optimized organization makes the distribution of air flow organization much more satisfying.

Related Dissertations

  1. Study of the Inner Flow of Vortex Stage and the Vibrancy of Rotor System in High Vacuum Dry Pump,TH314
  2. Numerical Simulation on Air Distribution in Super Large Space Underground Building,TU834
  3. Air Flow Simulation of Mini-environment in the Industrial Clean Room,TU831.8
  4. Indoor air quality and flow Relationship,O354
  5. The CAD/CFD Research on the Modern Design Method of Multi-blade Centrifugal fan for Air conditioning System,TU831
  6. Numerical Simulation Method in Coal-fired Electric Power Plant 300MW Unit Bag Filter Change Air Flow Optimization Study,X701.2
  7. Design and Research of CT Machine,R197.39
  8. Study of An Embedded Chinese Medical Therapeutic Apparatus,R197.39
  9. Based on Modbus Protocol pressure medical gas distribution monitoring system development,R197.39
  10. Studies on a New Exhaled Breath Condensate Collection Apparatus Making and Its Clinical Applications,R197.39
  11. A new waterjet debridement equipment research,R197.39
  12. ARM-based portable Holter recorder remote research,R197.39
  13. The Research and Design on Wireless Endoscope Location System,R197.39
  14. Research on the Human-Computer Interaction of Portable Blood Glucose Meter,R197.39
  15. Research on the Feasibility of Building Large Medical Equipments Check and Treat Center According to the Resource Sharing Principles,R197.39
  16. The Research of Dazhu Chinese Medicine Hospital PACS System,R197.39
  17. The Research of Medical Instrument Human-computer Interface Usability Design,R197.39
  18. Design and Biomechanical Evaluation of Occipital Cervical Fusion Instrument,R197.39
  19. Research on Quality Assurance of CT Scaners and it’s Computerbased Auto-Testing System,R197.39
  20. Research of Blood Coagulation Detection Technique Based on the Principle of the Liquor Electrical Resonance,R197.39
  21. Development of the Fast Blood Glucose Meter with Constant Temperature Control Function,R197.39
  22. The Design of Skin-graft-making Puncher,R197.39

CLC: > Medicine, health > Preventive Medicine,Health > Health care organizations and career ( Health Management ) > Health care systems and institutions > Hospitals, general hospitals > Medical Devices \u0026 Equipment
© 2012 www.DissertationTopic.Net  Mobile