Dissertation > Excellent graduate degree dissertation topics show

Effects of Hemocoagulase on Perioperative Blood Loss and Coagulation in Patients with Low Molecular Heparin Undergoing Total Hip Replacement

Author: WangDan
Tutor: MaHaiChun
School: Jilin University
Course: Clinical
Keywords: LMWH Hemocoagulase THR Coagulation Function
CLC: R687.4
Type: Master's thesis
Year: 2011
Downloads: 54
Quote: 0
Read: Download Dissertation

Abstract


Subject: Effects of hemocoagulase on perioperative blood loss and coagulation in patients with low molecular heparin undergoing total hip replacement.Objective: To investigate the effects of hemocoagulase in reducing perioperative blood loss in patients with low molecular heparin undergoing total hip replacement and study its effects on perioperative blood coagulation function so as to provide objective basis for better clinical usage of hemocoagulase. Methods: Fourty ASA I-III patients undergoing total hip replacement under general anesthesia were randomly and double blinded experiment. We excluded the patients suffering from deep vein thrombosis through CDFI. The fourty patients received LMWH for 4000 IU im 12 hours preoperatively. And then the fourty patients randomly received hemocoagulase for 2U iv or mannitol for 50 mg iv 10 minutes preoperatively. The perioperative and postoperative 24 hours bleeding volume was measured respectively; meanwhile, measuring the indices of blood coagulation function preoperative, immediately, 24 hours after operation respectively. We measured the deep vein thrombosis through CDFI 5 days after operation. After the experiment finished, we set Group I that received for hemocoagulase 2U iv 10 mins preoperatively; Group II that received mannitol for 50 mg iv 10 minutes preoperatively. Results:(1)The perioperative and postoperative 24 hours bleeding volume in Group I was less than that in Group II ( P < 0. 01 during operation and P < 0. 05 after operation ); (2) In Group I, RBC, Hb, HCT and PLT immediately and 24 hours after operation were not significantly lower than preoperation ( P>0. 05). (3) In Group II, RBC and Hb immediately after operation were lower than preoperation ( P < 0. 05); and HCT immediately after operation was lower than preoperation ( P < 0. 01); and RBC and Hb 24 hours after operation was lower than preoperation( P < 0. 05); and HCT was lower than preoperation( P < 0. 01).(4)In both groups, APTT, PT, Fbg immediately and 24 hours after operation were not significantly shorter than preoperation (P>0. 05). (5)There are 2 patients in Group I and 1 patients in Groups II suffering from DVT. Conclusion: Preoperative use of hemocoagulase(2U) reduces bleeding volume and hemocoagulase is better in safety.

Related Dissertations

  1. A Laboratory Study on the Influence of Coagulation Function in Pregnant Rats Injecting Amniotic Fluid Components,D919.1
  2. Two kinds of low molecular weight heparin (LMWH) production technology and quality standard,TQ464.5
  3. Efficacy Analysis of Low Molecular Weight Heparin for Preventing Venous Thromboembolism after Gastrointestinal Surgery,R656
  4. Primate -specific expression gene TCP10L function of,Q953
  5. Purification, Characterization and Pharmacodynamic Activity of Proteases and Its Isoenzyme from Nereis Virens,R96
  6. Study on Therapeutic Effects of Heparin on ALI/ARDS by Inhibiting the Activation of the p38 MAPK and NF-κB,R563.8
  7. Cloning Orthologous Transcription Factors and the Primary Study on Dynamics of the Indica and Japonica Genome Differentiation in Rice (Oryza Sativa L.),S511
  8. Study of Activin Signal Transduction on Macrophages Mediated by Activin Receptor Interacting Protein 2,R392
  9. The Expression of PKC and MAPK in Rats Renal with Pregnancy Induced Hypertension and Effects of Low Molecular Weight Heparin on Nephropathy,R714.246
  10. Cloning, Expression and Directed Mutagenesis of Xylanase Gene from Aspergillus Usamii,Q78
  11. Clinical Research of Acute Hypervolemic Hemodilution,R457
  12. Blood Platelet Level and Coagulation Function in Severe Acute Pancreatitis,R657.51
  13. Study of a Novel Serine/Threonine Protein Kinase Clone and Its Primary Biological Function,R341
  14. The Study of Different Dose’s Low Molecular Weight Heparin(LMWH) on Vascular Morphological Changes of Acute DVT in Rats,R654.3
  15. The Protective Effect of Hemocoagulase on Blood Conservation of Patients during Intracardiac Surgery with Cardiopulmonary Bypass,R726.5
  16. Hemocoagulase , desmopressin abdominal surgery patients coagulation function,R614
  17. Hemocoagulase with Slounase applications in orthopedic surgery contrast observation,R614
  18. Buzhongyiqitang Therapy after Total Hip Replacement Clinical Observation of Qi Deficiency Fever,R274.9
  19. The Interactions between Serine/Threonine Protein Kinase and FHA Substrate in Sulfolobus Tokodaii,Q93
  20. Hemostatic Effects Evaluation of Heamocoagulase Agkistrodon and Its Mechanisms,R285
  21. The Clinical Study on the Abnormality of Blood Lipids and Coagulation in Type 2 Diabetic Nephropathy,R692.9

CLC: > Medicine, health > Surgery > Orthopaedic Surgery ( movement system diseases,orthopedic surgery ) > Orthopedic surgery and surgery > Joint Surgery
© 2012 www.DissertationTopic.Net  Mobile