Dissertation > Excellent graduate degree dissertation topics show

Study for Dynamic Changes of Serum Neuron Specific Enolase and Matrix Metalloproteinases in Patients after Severe Traumatic Brain Injury and the Correlative Clinical Indications

Author: HuangZhiChun
Tutor: TianXinHua
School: Fujian Medical
Course: Surgery
Keywords: severe traumatic brain injury MMP-2 MMP-9 NSE
CLC: R651.1
Type: Master's thesis
Year: 2011
Downloads: 15
Quote: 0
Read: Download Dissertation

Abstract


Objective:To investigate the changes in the serunm levels of neuron specific enolase and matrix metalloproteinases-2 and matrix metalloproteinases-9 and their clinical indications in the patients after severe traumatic brain injury.Method:A prospective control study was carried out.The serunm from 56 sTBI patients and 20 normal persons were collected to measure the levels of NSE、MMP-2 and MMP-9 by using ELISA and analyzed the change trend of them together with Glasgow Outcome Scale.Result:The serum levels of NSE、MMP-2 and MMP-9 were significantly higher in the brain trauma group than those in the control group(P<0.01). The serum levels of NSE peaked on 5th day,although dropping on the 7th day after brain trauma ,was significantly higher in the brain trauma group than that in the control group. The serum levels of MMP-2、MMP-9 peaked on 1st day and the second peak appeared on 5th day and than dropping on 7th day. The serum levels of NSE、MMP-2 and MMP-9 were significantly higher in the patients with poor prognoses group than those with good prognoses group(P<0.01).Conclusion:NSE、MMP-2 and MMP-9 of the serum were involved in the pathological process of acute brain injury, and might play an important role in secondary brain injury .Determination of their contents was of clinical importance for evaluation of the severity of injury and outcome prediction.

Related Dissertations

  1. Clinical Significance of STAT3 and MMP-2 in Hepatocellular Carcinoma.,R735.7
  2. Expression of MMP-9 and p63 in Oral Squamous Cell Carcinoma and Clinical Significance,R739.8
  3. Experimental Study on 420nm Intense Pulse Light in Animal Acne Model,R758.733
  4. Initial Research on the Expression and the Significance of Cx-43、 Caspase-3 and MMP-2 in Endothelial Cells in Atherosclerosis in Human Coronary Artery,R541.4
  5. Combined Detection of Tumor Markers in the Diagnosis and Treatment of Lung Cancer to Determine the Clinical Significance,R734.2
  6. Study on Expression of MMP-8 on Experimental Periapial Periodontitis is Infected by Enterococcus Faecalis,R781.34
  7. The Effect of Mild Hypothermia Combined with TP-5 to T Lymphocyte Subsets and Prognosis of Patients with Severe Traumatic Brain Injur,R651.15
  8. The Influence of Cold Self-bloodcardioplegia to MMP-2 Concentration for Infant with Cardiopulmulnary Bypass,R726.5
  9. The Experimental Study of Atorvastatin with Neuroprotective Effects by Inhibiting MMP-9 and Upregulating TIMP-1 Expression in Rat Stroke Model of Focal Cerebral Ischemia/Reperfusion,R743.33
  10. Galectin-3, MMP-2 and MMP-9 expression in colorectal carcinoma and their correlation,R735.3
  11. MMP-2, VEGF, CD105, Ki67 in small cell lung carcinoma and prognosis of,R734.2
  12. Rat hepatoma evolution of three biochemical factors and related drugs Intervention,R735.7
  13. A Study of the Expression of MMP-1 and TIMP-1 at the Enthesiopathy and the Intervention Effects by Acupuncture,R87
  14. Study of Upregulation of Matrix Metalloproteinase-2 Expression Mediated by ERK1/2/MAPK Signaling Pathway Promoting Drug Resistance in Osteosarcoma,R738.1
  15. The Role of MMP-2 in the Pathogenesis and Relapse Mechanism of Nasal Polyps,R765.25
  16. The Effects of Autophagy on Cardiomyocytes Viability and Mitochondrial Membrane Potential in Sepsis,R459.7
  17. Effect of Rosuvastatin on Expression of MMP-9 mRNA and Protective in Cultured Human Monocyte-macrophages Cell Induced by Oxidized Low Density Lipoprotein,R965
  18. Influence of Atrovastation on MMP-9 and TIMP-1 of Experimental Intracerebral Hemorrhage in Rats,R965
  19. Effects of Tobacco on Matri Metalloproteinase-9 between Gingival Crevicular Fluid in Subjects with Chronic Periodontitis and Human Gingival Fibroblasts,R781.4
  20. The Effects and Mechanisms of Racanisodamine on Form-deprivation Myopia in Guinea Pigs,R778.11
  21. The Research on MMP-10 Expressing in Human Benign and Malignant Breast Tissue,R737.9

CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery > Brain
© 2012 www.DissertationTopic.Net  Mobile