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The Evaluation of Renal Perfusion with Contrast-enhanced Ultrasound in Patients with Liver Cirrhosis at Different Stages
Author: WangRuiLi
Tutor: WangJian
School: Shanxi Medical
Course: Medical Imaging and Nuclear Medicine
Keywords: Ultrasound Contrast agent Cirrhosis of the liver Kidney
CLC: R575.2
Type: Master's thesis
Year: 2011
Downloads: 21
Quote: 0
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Abstract
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Objective: real-time ultrasound imaging techniques combined with time - intensity curve quantitative evaluation of varying degrees of liver cirrhosis in patients with renal perfusion, looking for contrast-enhanced ultrasound the quantitative parameter variations and cirrhosis course of relationship abnormal clinical basis for the discovery of cirrhosis renal perfusion . Methods: patients with liver cirrhosis 31 cases of decompensated cirrhosis group of 13 patients with decompensated cirrhosis group, 18 patients, and all patients with cirrhosis of the liver, according to the Child-Pugh score of liver function score; normal control group of 30 patients . Two-dimensional cross-sectional images of the ultrasound to obtain maximum long axis of the right kidney, the renal perfusion observed in the real-time ultrasound imaging conditions (mechanical index 0.07) and save the contrast dynamic image, and then application QontraXt software for quantitative analysis of renal cortical blood flow perfusion , quantization parameters include the peak intensity, which was the ratio of the area and the peak intensity of the peak time, the degree of the tip of the curve under the curve. Normal group control, compensatory and decompensated cirrhosis patients with renal perfusion and time - intensity curve quantization parameter changes, and cirrhosis of the liver in patients with renal perfusion parameters and Child-Pugh score correlation analysis. Results: ① Compared with normal group, the peak intensity of the decompensated cirrhosis group, reduce the peak intensity ratio of the measured value, the difference was statistically significant (P lt; 0.05), time to peak measured value increased, but the difference was not statistically significance (P gt; 0.05); decompensated cirrhosis group peak intensity, peak intensity ratio of the measured value to further reduce the difference was statistically significant (P lt; 0.01), time to peak measured values ??significantly increased, the difference was statistically significance (P lt; 0.01). Compared with decompensated cirrhosis, decompensated cirrhosis group peak intensity measured value to reduce the difference was statistically significant (P lt; 0.01), reduce the measured value of the peak intensity ratio, the difference was statistically significant (P lt ; 0.05). The area under the curve between the groups, the curve of the sharpness difference was not statistically significant (P gt; 0.05). (2) cirrhosis group ultrasound contrast quantitative parameters of peak intensity and peak intensity ratio with Child-Pugh score were negatively correlated (P lt; 0.01, P lt; 0.05); peak time curve the sharpness, the area under the curve and Child -Pugh score value does not exist correlation (P gt; 0.05) Conclusion: Ultrasound contrast with time - intensity curve quantitative analysis of the varying degrees of liver cirrhosis in patients with renal perfusion. Changes in the ratio of the peak intensity and the peak intensity of the the kidney cortex ultrasound contrast parameters cirrhosis of the liver cirrhosis severity is closely related to better reflect the renal blood flow in patients with cirrhosis of the liver perfusion parameters.
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CLC: > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Liver and gall bladder disease > Cirrhosis
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