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Of portal hypertension (portal hypertension, PHT) is a common clinical syndrome, refers to a variety of causes of portal vein blood flow is blocked and (or) blood flow, leading to the portal vein and its branch intravascular pressure rise, with collateral loop formed by a group of clinical syndromes, including ascites, esophageal - gastric variceal bleeding (Esophagus-variceal bleeding, EVB), hepatic encephalopathy, hepatorenal syndrome, hepatopulmonary syndrome, portal hypertension, stomach, etc.. Is generally believed that the various causes of cirrhosis is a major cause of portal hypertension, the proportion of 80% to 90%, hepatitis, cirrhosis is a major cause of cirrhosis. Spleen, the establishment of the collateral circulation and open, ascites three major clinical manifestations of portal hypertension. Human serum albumin (Human albumin, HA) is one of the commonly used drugs in patients with cirrhosis input too quickly can lead to rapid increase in portal pressure induced upper gastrointestinal bleeding. Changes in hemodynamic parameters of this study using color Doppler ultrasonography detected in patients with cirrhosis and portal hypertension input human blood albumin at different time points, and further explore the input of human serum albumin best suitable speed, to provide theoretical guidance of clinical care basis. Pancreatic Medicine cirrhosis and portal hypertension patients to stay in the First Hospital of Jilin University, for January 2010 to March 2011, 58 cases were randomly divided into two groups, namely conventional infusion group (45 minutes losers a human serum albumin ) and the experimental group (30 minutes losers a human serum albumin), the two groups of patients enter the colloidal solution are Auchter enamel-Mart Pharmacy production Co., Ltd. 20% human serum albumin 50ml (containing 10g) and Application Philips IU22 color Doppler ultrasonic diagnostic apparatus to detect patients at different time points, the direct measurement of the portal vein diameter and peak velocity analysis of changes in the parameters of portal hemodynamics by the SAS software for statistical processing. The conventional group measurement time point of 0 minutes, 15 minutes, 45 minutes; measurement time point of the experimental group to 0 minutes, 15 minutes, 30 minutes. The two sets of input human serum albumin in 15 minutes, the portal blood flow significantly increased, but statistically meaningless input before and after blood flow did not change significantly. The two groups of portal vein diameter, mean blood flow velocity and portal vein pressure changes are not so obvious, there was no statistically significant difference. In conclusion, this study during the experiment, 58 cases of no case of vascular bleeding, hemodynamic changes of color Doppler ultrasound to portal hypertension to provide accurate, repeatable quantitative indicators, clinical applications value. Therefore, the experimental group entered within 30 minutes 20% human serum albumin a 50ml (containing 10g) is feasible.
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