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Retinal vascular occlusive disease is a common disease of serious damage to visual function. Traditional conventional treatment such as massage, puncture, oral medication, etc., require a longer time, and the healing effect is not obvious. Magnetic drug targeting the drug delivery is loaded onto magnetic nanoparticles, by means of an external magnetic field, will be directed at the target carrier to release the drug contained positioned to play a role focused on the lesion, with high targeted, quick and low- toxic characteristics. The method was applied magnetic drug targeting retinal vascular obstructive diseases of particular clinical significance. At present, the domestic for magnetic drug targeting the overall level of development is still in the basic research stage, there are still many deficiencies, and lack of retinal vascular thrombosis on magnetic drug in capture efficiency and other aspects of research. To this end, the paper combined with Shanghai Jiaotong University Medical Technology Fund Project \Drug capture efficiency calculation model and influencing factors such as the detailed study. In this paper, the work done and the results obtained are as follows: 1, according to the characteristics of retinal blood vessels and small blood vessels within the non-Newtonian fluid flow state, chose Carson model represents the inner blood characteristics, choose the Newtonian model represents the outer layer of the plasma properties. Different from previous studies using infinitely long permanent magnets, paper, rectangular permanent magnets, as an external magnetic field source, based on two-phase Carson - Newtonian model to analyze drug-carrying magnetic nanoparticles in the blood vessels affected by magnetic and hydrodynamic effects trajectory , the establishment of three-dimensional space of the magnetic particle capture efficiency of the theoretical formula, this model is more accurate than the traditional model; thereby obtain magnetic drug optimization model to capture volume. 2, using the Runge-Kutta algorithm and the dichotomy through Matlab numerical simulation, analysis of intravascular flow field and the magnetic field distribution obtained for different models of blood flow, magnetic particle trajectory, capture efficiency, and compared the plane and three-dimensional capture efficiency . The simulation results show that the use of non-Newtonian fluid may better describe blood Carson, rectangular permanent magnet magnetic field generated more efficiently; other conditions unchanged, the particle radius greater than the radius of the larger magnetic material, the magnetic field strength is, the magnet and the The smaller the distance vessels, blood vessels smaller the radius, the greater capture efficiency; different particle radius, the magnetic substance when the radius ratio of 0.75 to capture the largest volume of the drug to capture the magnetic pharmaceutical preparation process, can refer to this value, to system optimization . 3, based on the retina causes retinal vascular thrombosis and clinical manifestations, different situation, this paper established a rigid and elastic artery thrombosis model, and with Gambit and Fluent CFD simulations for the model, theoretically analyzed blood clots in the blood flow, pressure and other effects, as well as in magnetic drug targeting systems, embolization size, blood vessel elasticity, magnetic field range of the magnetic particle capture efficiency and other implications for clinical treatment provides a theoretical basis. 4, through in vitro analysis of the solution flow rate and magnetic field strength of the magnetic particle capture efficiency, verify the paper established the validity of the model to capture the magnetic particles, and it is accurate and stable than the traditional model. Meanwhile the problems encountered during the experiment and solutions, such as magnetic particle capture balance, and even human experiments on subsequent experiments provide a reference. In summary, the method is applied to the magnetic drug targeting retinal vascular obstructive disease, treatment can improve drug efficacy, with a wide range of uses and potentially huge market demand. This research work and achievements of magnetic drug targeting methods used in the treatment of retinal vascular occlusive disease provides a theoretical guidance.
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