Dissertation > Excellent graduate degree dissertation topics show

Core-Shell Nanoparticles: Preparation and the Encapsulation and Release of Drugs

Author: WuLiLi
Tutor: ZhuXiaoLi
School: Jinan University
Course: Polymer Chemistry and Physics
Keywords: Casein Methyl methacrylate Butyl acrylate Graft polymerization Core - shell nanospheres
CLC: TQ460.1
Type: Master's thesis
Year: 2011
Downloads: 43
Quote: 0
Read: Download Dissertation

Abstract


In this thesis, the emulsion polymerization process and is not using any emulsifiers and stabilizers used in the presence of t - butyl hydrogen peroxide (TBHP) , casein (CA) of methyl methacrylate (MMA) and acrylic acid as initiator, respectively butylacrylate (BA) in the CA on the graft polymerization, a diameter of about 150 nm having a core - shell structure of the PMMA / CA PBA / CA nano composite latex particles were prepared . Characterized by TEM results confirm a core-shell structure of the latex particles , the cores were hydrophobic PMMA, PBA, the housing for the hydrophilicity of the CA . Using laser particle size analyzer to test the particle size and size distribution of the latex particles , chloroform as solvent using Soxhlet extraction test grafting efficiency of PMMA, PBA . The effects of reaction temperature, and the amount of initiator and core-shell raw material quality than , the the materials total concentration of monomer conversion , grafting efficiency of PMMA and PBA , latex particle size and its distribution impact . Preparation of PMMA / CA core - shell nanoparticles , the monomer conversion and the latex particle size with reaction time changes in the experimental results show that : the beginning of the polymerization of 20 min , the latex particle suddenly reduced and then remained unchanged for 30 min single body conversion rate of 70 % to 73% within 3 h . When MMA conversion rate in the temperature controlled at 70 ℃ and 80 ° C , of TBHP dosage control in CA quality of 0.18% to 0.36 % , the the MMA / CA mass ratio of 4 , the total concentration of materials does not exceed 10 % of the conditions of grafting efficiency and PMMA higher than 75 % . CA - MMA total content reached 30% , the gel , this is because the shell of the latex particles is hydrophilic CA , contains a large amount of the amino group, a hydroxyl group and a carboxyl group , with water to form a strong hydrogen bonding interactions , with the system the CA content increases , the viscosity of the system increases rapidly. Preparation of PBA / CA when the core - shell nanoparticles experimental results show a clear core-shell : BA / CA mass ratio of 4, TBHP attributable CA quality of 0.22 % , the total content of Ca and BA in 10 % , 75 ° C the reaction can be obtained the structure of the latex particle, and can obtain higher monomer conversion rate and PBA graft efficiency . Thereafter continue to improve any of the above experimental parameters are the conversion rate of the BA , the grafting efficiency of the PBA , latex particle size distribution, etc. have a negative impact . The core-shell emulsion prepared dialysis using gas chromatography detection of residual monomer , and then use the the ultrasound law or oscillation prepared load paclitaxel core-shell particles of paclitaxel in the core-shell particles coated .

Related Dissertations

  1. Influence of CPP-ACP Pretreatment on Resin-dentine Bonding,R783.1
  2. Study on the Toughness Improvement of Green Plastic-Poly (Lactic Acid),TQ320.1
  3. Study on Thermally Conductive Polymer Composites,TB332
  4. Study on Synthesis and Properties of Phosphate/Siloxane/Acrylate Grafted Waterborne Epoxy,TQ323.5
  5. Construction of HBD-3 Gene Breast-Specific Expression Vector and Eukaryotic Expression,Q78
  6. The Preparation and Properties of the Composites of Polymethylmethacrylate and Functionalized Multi-walled Carbon Nanotubes,TB383.1
  7. Preparation of Molecular Imprinting Polymer on Silica Gel Particles for Alkaloid and Specific Binding Property,O631.3
  8. Casein Peptide Preparation and Research,TQ464.7
  9. A Study on the Synthesis and Properties of Acrylamide-based Polymers by Living Radical Polymerization,O631.3
  10. Preparation and Characterization of UV-curable Hybrid Coatings and UV Curable Conductive Adhesive,TB383.1
  11. Synthesis of Star Polymer and Organic/Inorganic Hybrid Materials by the Method of Living Free Radical Polymerization,O631.5
  12. Antioxidative Peptides Derived from Casein in Enzymatic Membrane Reactor,TQ936
  13. Preparation and Properties of Polymer/MgAl Layered Double Hydroxide Nanocomposites,TB383.1
  14. Preparation of 4% Cartap Microcapsule Granules,TQ450.63
  15. The Adsorption Behavior of Heavy Metal Ions on Modified Starch and PMMA,X703
  16. Amphiphilic Polymer Grafted Paper-Based Membrane,TB383.2
  17. Preparation and Characterization of Some New Acrylate Monomers and Research of Their Polymerization,O631.5
  18. Study on Miscibility of PLA and PMMA,O631.3
  19. The Study of Structures and Properties of PMMA/Core-shell Impact Modifier Blends,TQ316.334
  20. Synthesis and Application about Nano-Rod St-MMA Copolymer,O631.3
  21. Emulsion Polymerization of Methyl Methacrylate Initiated by Novel Initiator,TQ316.334

CLC: > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > General issues > Basic theory
© 2012 www.DissertationTopic.Net  Mobile