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The Level and Clinical Significance of Serum 8-iso-prostaglandin F2α in Patients with Acute Cerebral Infarction

Author: ZhaoMingMing
Tutor: ZhaoQing
School: Jilin University
Course: Neurology
Keywords: 8-iso prostaglandin F2α Acute cerebral infarction ELISA Clinical significance
CLC: R743.3
Type: Master's thesis
Year: 2011
Downloads: 39
Quote: 0
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Abstract


Currently, cerebrovascular disease in the elderly has become a major disease which is hazard to life and health. Cerebrovascular disease has been paid more attention because of its high mortality and high morbidity. The incidence of ischemic cerebrovascular disease (ICVD)is significantly high. Therefore, to strengthen the understanding of ischemic cerebrovascular disease, to reduce the incidence of mortality and reduce morbidity is significant. Nowadays Oxidative stress mechanism has been taken seriously in the pathogenesis of ischemic cerebrovascular disease. However, the relationships among the degree of oxidation after acute cerebral ischemia, oxidative injury and traditional risk factors of cerebral vascular disease are rarely reported.Relationships between the degree of oxidative damage and neurological deficits are also rarely reported. It has been reported dissociative 8-iso-PGF2a which has been considered as a biomarker of oxidative stress can be stable in plasma, urine and various body fluids in vivo.The present resceach had observed the change of serum 8-iso-PGF2a content in acute ischemic cerebrovascular disease and then approach its clinical significance.143 patients with Acute Cerebrovascular Ischemic disease (ACI) were selected strictly according to inclusion and exclusion criteria from April of 2009 to December of 2010 at the department of Neurology in China-Japan Union Hospital, Jilin University. All patients in case group including 9(?) men and 51 women accorded with the diagnostic standard of the national fourth Meeting of cerebrovascular disease in 1996.All the patients treated within 24 hours in case group were diagnosed by head CT or MRI within a week since pathogenesis. Record risk factors of ischemic cerebral vascular disease(ICVD) as sex, age, smoking history, diabetes and hypertension, all these formation was confirmed by familiality or clinical histories. Measure blood pressure, glucose,LDL-C of ACI patients. ACI patients were divided into groups with the infarct size and the extent of neurological impairment. By measuring all patients’8-iso-PGF2a in serum, to Analysis the changes of serum 8-iso-PGF2a content in ACI, the relationship among 8-iso-PGF2a content, hepertention and infarct sizes,as well as the relationship between 8-iso-PGF2a and degree of neurological deficits.Result:The level of serum 8-iso-PGF2a in ACI group was significantly higher than the control group(p<0.05).And ACI group The level of serum 8-iso-PGF2a was higher when patients with age>45,diabetes, hyperlipidemia, hypertension (p<0.05),results were Statistically significant. Serum 8-iso-PGF2a in different blood pressure level were significantly different, which was higher in 2、3grate hypertention than I grate, p<0.05. And it was also higher in3 grate hypertention than 2grate p<0.05. results were statistically significant.The level of serum 8-iso-PGF2a was significantly different with different lesion size in ACI group,it was higher in patients with massive cerebral infarction.Along with the increase of infarction volume the level of serum 8-iso-PGF2a was elevated obviously(p<0.05).We also found that in neurological deficit group more serious the ischemic was the level of 8-iso-PGF2a was higher.In moderate to severe neurological deficits patients levels of plasma 8-iso-PGF2a increased higher than mild group p<0.05, results were statistically significant..Conclusion:1. In acute phase, level of plasma 8-iso-PGF2a of ACI patients was significantly increased,it can be considered as an early sensitive indicator which reflected the level of cerebral hypoxic-ischemic injury, it also had some clinical significance on diagnosis of acute cerebral infarction.2. Level of Serum 8-iso-PGF2a was significantly higher when ACI patients run hypertension, diabetes, LDL levels, age>45 years simultaneously.3. In acute phase, level of plasma 8-iso-PGF2a of ACI patients was related to infarct volume and severity of ischemic.

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CLC: > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease > Acute cerebrovascular disease ( stroke)
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