Dissertation > Excellent graduate degree dissertation topics show

The Relationship between DNA Methylation and Hematological Malignancies

Author: ZhangWei
Tutor: ZhangLianSheng
School: Lanzhou University
Course: Internal Medicine
Keywords: DNA methylation mechanism diagnosis treatment detection method
CLC: R733
Type: Master's thesis
Year: 2011
Downloads: 151
Quote: 0
Read: Download Dissertation

Abstract


Tumor epigenetics is a new subject, mainly including DNA methylation, histone modification and chromatin remodeling, genomic imprinting and the coding RNA control, etc. Among them, the DNA methylation and tumor relationship is the research focus. Gene DNA methylation of DNA C5 cytosine methyl shift enzyme (DNA methyltransferase, Dnmt) catalysis, Dnmt to S-adenosine state-of-art 1-methionine (S-adenosylmethionine, SAM) for methyl donors, will methyl transferred to cytosine the fifth on carbon atoms. The influence factors of DNA methylation:DNA methylation transferase and histone methylation, diet, and other factors. DNA methylation tumours, including gene mutations of the pace of molecular mechanism of low, DNA methylation related gene expression, effects of DNA methylation on high the influence of gene expression and DNA methylation shift enzyme expression to increase the influence of DNA methylation. DNA methylation on blood disease diagnosis have important clinical value, in many cases, methylation earlier than the obvious malignant phenotype appear, and abnormal DNA methylation loci, specific genes with tumor-specific CpG island methylation is probably the most compelling tumor early detection of molecular indexes. Due to high in DNA methylation in malignant blood widespread make malignant blood to methylation, this paper treatment to be drugs to methylation reading. DNA methylation in most blood cancers exist the same cancer gene and tumor-suppressor genes, maybe onset starting mechanism for the same and the performance of different blood disease. Along with the development of methylation correlation with tumor the deepening of the research, there is a growing realization that methylation change and traditional between the prognostic indicators close contact. Mainly including four aspects:(1) the methylation change and staging, stages have obvious correlation. (2) the DNA methylation can promote abnormal invasion and metastasis of tumor. (3) methylation can be used as an independent predictor of tumor recurrence. (4) methylation affect survival. Detection methylation changes helped, and prognosis for clinical condition monitoring and risk assessment, provides the basis. Gene promoter and its nearby area CpG methylation is multiple genes realize to express (pause) and genetic signature important way, by means of measuring the CpG island promoter methylation state understand gene is to express, provides for the study of gene expression in DNA level of important ways, this paper lists some DNA methylation testing method. DNA abnormal methylation is the blood system cancer an important molecular mechanism, especially the tumor-suppressor genes methylation make its inactivation is most important, promoter methylation in abnormal cellular canceration process is-a early, frequent events, can be used as a cancer sensitive biology markers, methylation, further research is important for both the research for clinical also has important practical value.

Related Dissertations

  1. Studies on the Synthesis and Technology of Dipentaerythritol and Its Derivative,TQ223.164
  2. Design and Development of Application Programme for Fault Analyzer Based on Wince Platform,TP311.52
  3. Study on Hermetic EDGE Sealing of Anodic Bonding for Vacuum Glazing,TQ171.1
  4. Preparation and Performance of Molecular Imprinted Polymers for Rhodamine-B and Rhodamine-6G,O631.3
  5. Reactive Hot-Pressing and Mechanical Properties of （ZrB2-ZrO2）/BN Composites,TB332
  6. Research on Mechanism Analysis and Modeling Simulation of Horizontal Well Tractor,P631.83
  7. The Effect of Composite Additive on the SNCR,X701
  8. Research on the 6-Dof Fault Tolerant Control of the Vibration Isolation Platform with Eight Actuators,TB535.1
  9. Kunming Transient Population Community Present Situation, Question and Countermeasure Preliminary Study,C924.25
  10. Tongue Feature Extraction and Research of Fusion Classification,TP391.41
  11. Research on Feature Extraction and Classification of Tongue Shape and Tooth-Marked Tongue in TCM Tongue Diagnosis,TP391.41
  12. Fault Diagnosis Research on Three-Tank System,TP277
  13. Effects of acupuncture on stroke recovery associated with depression and physical disabilities,R246.6
  14. The Research of the Dynamic Process of Advertising Public Opinion,G206
  15. Process and Mechanism of Eucalyptus Pulp Bleaching Catalysed by Cu2+/Co2+,TS745
  16. The Environmental-Friendly Method and Process of Removing Non-Cellulosic Matters from Bamboo for Textile Fiber,TS652
  17. Minority environmental rights,D922.68
  18. Preparation and Anticorrosion Properties of Doped Polyaniline/Epoxy Coating,TQ637
  19. Research on the Key Technology of Waterborne Transport Security System,U698
  20. Synthesis and Biocompatibility of different types of hydrophilic surface - modified polyurethane,R318.08
  21. Research of Communication Mechanism in the Distributed Network Based on Mobile Agent,TP393.02

CLC: > Medicine, health > Oncology > Hematopoietic and lymphoid neoplasms
© 2012 www.DissertationTopic.Net  Mobile