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Methylation Status of Promoter of SPARC in Epithelial Ovarian Cancer and Clinical

Author: ZhuZuo
Tutor: JinPing
School: Lanzhou University
Course: Obstetrics and Gynaecology
Keywords: Ovarian tumors DNA methylation Tumor Gene Suppression
CLC: R737.31
Type: Master's thesis
Year: 2011
Downloads: 25
Quote: 0
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Abstract


Objective To investigate the SPARC gene methylation status in the organization of epithelial ovarian cancer and clinical significance . The method detected using methylation-specific polymerase chain reaction (MSP) for 2008-2010 provided by the Department of Pathology , the First Affiliated Hospital of Lanzhou University , 40 patients with primary epithelial ovarian cancer , 30 patients with benign ovarian tumors and 10 normal ovarian paraffin-embedded tissue SPARC gene promoter region methylation status . Results of the SPARC gene promoter methylation in the incidence of epithelial ovarian cancer tissue , benign tumors and normal tissue were 65.0% ( 26 / 40 ) , ( 8 / 30 ) 26.7% (2 / 10) 20.0% , SPARC methylation rate of cancer tissue was significantly higher than that in benign tumors and normal ovarian tissue ( P lt; 0.05 ) , benign tumor tissue and normal tissue compared with no statistical significance ( P gt ; 0.05) SPARC methylation rate differences between different histological types of no statistical significance ( P gt ; 0.05 ) . Poorly differentiated carcinoma group SPARC gene promoter methylation was higher than in well-differentiated and moderately differentiated carcinoma group ( P lt; 0.05 ) , compared in the differentiation groups with well-differentiated group showed no significant difference (P gt; 0.05), clinical stage Ⅲ and Ⅳ SPARC gene promoter methylation was higher than ⅰ and Ⅱ ( P lt; 0.05 ) , compared with no ascites ascites group difference was statistically significant ( P lt; 0.05), lymph node metastasis group compared to the difference had no statistical significance ( P gt ; 0.05) . Conclusion SPARC gene promoter region abnormal methylation plays an important role in the development of epithelial ovarian cancer and epithelial ovarian cancer differentiation and clinical stage .

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CLC: > Medicine, health > Oncology > Genitourinary tumors > Female genital tumors > Ovarian tumors
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