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Purpose and Background: SE refers to the partial or generalized epileptic seizures occur frequently in a short time, generalized seizures in two episodes interval did not recover consciousness; generalized or partial seizures last for more than 30min. Is a common neurological emergency, the incidence of epilepsy in 11 ‰ ~ 140 ‰, the general population is 0.3 ‰ ~ 8 ‰, short-term mortality rate can be as high as 3% to 46%, 5% to 50 disabled %. Rapid control of seizures and aggressive life-sustaining function is to save the SE of the key. SE will begin treatment abroad has been defined as the time of 5min, China has not yet attracted enough attention to clinicians, often lasted 30min state occurs only after the start of treatment. This retrospective analysis of 86 cases of SE clinical features and treatment through, and to explore the impact of factors related to its therapeutic effect for SE clinical diagnosis and treatment of the recent judgment of reference. Materials and Methods: This was a retrospective study, data from the Department of Neurology, First Hospital of Jilin University, January 2006 to December 2010 patients hospitalized SE, SE meet diagnostic criteria, a total of 86 cases, and the exclusion of serious injury caused by brain stem de brain tonic state, pseudo seizures continuous state, transient ischemic attack, hyperventilation and other cases. For all the patient's gender, age, medical history, treatment conditions and incentives etiology, clinical manifestations and specific seizure types, complications, treatment and the results of the laboratory examinations to summarize, analyze, and SE-related treatment and prognosis factor. Results: 86 cases of SE patients: (1) Sex: 42 males and 44 females, male and female incidence ratio similar. (2) age: minimum 16 years, maximum 87 years, mean age 45.23 ± 18.39 years old. All ages are visible, where lt; 60-year-old young adults were 67 cases (77.9%), ≥ 60 years of age in 19 patients (22.1%). (3) cause: to symptomatic largest, accounting for 61 cases (70.9%); followed by primary, accounting for 25 cases (29.1%); (4) incentives: 36 cases occurred in patients with a history of epilepsy SE incentives including non-formal treatment and medication 20 cases (55.6%), mostly for drug reduction of excessive and sudden withdrawal; infection, fever six cases (16.7%), mainly as intracranial infections and respiratory infections; no obvious incentive to 6 cases (16.7 %); Other incentives include trauma 2 cases (5.6%), drinking one case (2.8%), fatigue 1 case (2.8%). Visible infection and not regular treatment and medication is the most common cause of SE. (5) seizure type: CSE accounted for 84 cases (97.7%), which accounted for 67 cases of GCSE, CPSE accounted for 17 cases; NCSE accounted for 2 cases (2.3%). (6) duration of attack: Duration ≤ 60min accounted for 76 cases (88.4%), 56 cases in which treatment is effective, partially effective in 6 cases, 14 cases; Duration gt; 60min accounted for 10 cases (11.6%), which treatment is effective in 4 cases, 6 cases. (7) seizure control time: seizure control time for a minimum of 10min, up to 16d. Of which 20 cases (23.3%) 30min complete control of seizures within, 40 cases (46.5%) 30min over complete control of seizures, 6 cases (7.0%) more than 50% reduction in seizures during hospitalization is not fully controlled, 11 cases (12.8%) episodes uncontrolled and persistent disturbance of consciousness abandon the treatment and discharged, 9 cases (10.5%) died. (8) Complications: Complications occurred in this group of patients, 42 patients (48.8%). 60min duration of attack less than 76 cases of patients with complications in 34 cases (44.7%), duration 60min or more complications occurred in 10 patients, 8 cases (accounting for 80.0%); 30min seizures under control within 20 patients with complications in 9 cases (accounting for 45.0%), 30min or more seizures under control in 40 patients with complications in 20 cases (50.0%); six cases more than 50% seizure reduction in patients with complications 3 patients (50.0%), 11 patients abandoned treatment complications occurred in 1 case (9.0%, because of the greater part of patients hospitalized in a relatively short time, found no significant complications), the death of 9 All patients with varying degrees of complication (100.0%). (9) treatment conditions: 86 patients, 34 cases within 24 h treatment, of which 9 cases (26.5%) seizures under control within 30min, 17 cases (50.0%) seizures under control for more than 30min, 7 cases (20.6%) ineffective treatment; 52 cases in more than 24h treatment, 11 cases (21.2%) episodes of 30min or less under control, 23 cases (44.2%) seizures under control for more than 30min, 13 cases of treatment failure (25.0%). Conclusion: The SE occurred in patients of all ages; common with symptomatic epilepsy; often caused by infection and irregular treatment and medication-induced; seizure type most of CSE. Epilepsy induced SE is a potential risk factor. Duration of attack and control the time and the SE treatment and prognosis (P lt; 0.05). Duration of attack and control of time is shorter, the better the effect, the smaller the chances of complications. Episodes lasting less than 60min disease had significantly better than those who lasts longer than 60min. Seizure control time ≤ 30min good effect.
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