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Purpose carbamylation erythropoietin hormone (Carbamylated erythropoietin, CEPO) clear cardioprotective effect , but the possibility of treatment of chronic heart failure (Chronic heart failure, CHF) No reported . Of this study was to establish the rat model of CHF , to be the CEPO intervention , observation of left ventricular remodeling . Methods Male Wistar rats were 90 , 10 randomly selected as a control group , and the rest of the intraperitoneal injection of isoproterenol (Isoproterenol, ISO) to establish the model of CHF . Modeling successful five weeks later , and then divided into CHF and CEPO group , the latter intraperitoneal injection CEPO 50μg/kg 2 times / week , CHF and control groups over the same period intraperitoneal injection of normal saline was detected after 4 weeks groups mouse hemodynamic indicators plasma B-type natriuretic peptide (Brain natriuretic peptide, BNP) level , and calculated left ventricular mass index ( Left ventriclar weight / body weight , LVW / BW ) . Results Compared with the control group , the CHF group left ventricular peak pressure (LVSP). Left ventricular pressure rise / fall rate (± dp / dtmax) a significant reduction in left ventricular end-diastolic pressure (LVEDP) was significantly higher (P <0.05) plasma BNP levels were significantly higher (P lt; 0.05), LVW / BW also significantly increased (P <0.05). Compared with the CHF group , CEPO group LVSP , ± dp / dtmax were significantly higher , while LVEDP is significant with lower ( P < 0.05 ) , plasma BNP levels significantly significantly reduce ( P lt ; 0.01 ) , LVW / BW significantly reduce (P <0.05). Conclusion the CEPO by improvement of left ventricular systolic and diastolic function , reduce plasma BNP levels , reducing left ventricular remodeling to improve the heart function of rats with CHF .
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