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Objective: of different activity 125 the I particles tumor implantation combined with TACE treatment the rabbit VX 2 hepatic tumor pathological changes and efficacy, and explore the best particle activity its role in the treatment of liver cancer. Methods: Healthy male New Zealand white rabbits, weighing 2.5 to 3.0 kg. Provided by the Experimental Animal Center of Nanjing Medical University, Nanjing First Hospital. Successful VX build a total of 96 2 liver xenograft model rabbit were randomly divided into four groups, namely: (1) control group (A group) liver xenograft model rabbit 12, implanted 0mCi 125 I particles; (2) simple 125 I particle implantation group (B) liver xenograft model rabbit 36, which according to the implantation of particles of different activity is divided into B1, B2, B3 , rabbit model of hepatic tumor in each group are 12, were implanted 1.0mCi 0.7mCi I 0.4mCi 125 particles; ③ 125 I particles TACE group (C group) liver transplantation tumor model in rabbits 36, which according to the implanted particles of different activity is divided into C1, C2, C3 group, each group liver xenograft model rabbit are 12, were implanted into 1.0mCi, 0.7mCi, 0.4mCi 125 I particles; ④ TACE alone group (D) liver xenograft model rabbit 12. Radiographic monitoring tumor size, tumor when the tumor diameter of about 2cm rabbit to accept seed implantation or TACE treatment the assessment which A, B, C groups before treatment TPS planning system, the B-guided implantation of different live degrees 125 I particles; C, D group in the DSA TACE treatment. Through before treatment, after treatment, 4 and 6 weeks of four-time observation point, observed a group of liver tumor volume change, the inhibition rate of change in the tumor tissue and normal liver tissue pathomorphological changes and changes in hematological indices. Results: 125 I particles before implantation tumor size of each group showed no statistical significance (P gt; 0.01). Each treatment group, tumor volume before and after treatment was statistically significant (P lt; 0.01) in group A were less than the same period in the control group (P lt; 0.01). Each treatment group in different post-treatment observation period, the inhibition rate of contrast were statistically significant (P lt; 0.05), about two weeks after treatment, the inhibition rate of the most significant changes. The inhibition rate of each treatment group difference two weeks after treatment is most obvious, with a statistically significant (P lt; 0.01) decreases gradually thereafter, but were higher than group D (P lt; 0.01). Treatment after six weeks in group B1 and B2 groups C1 group and the C2 group, tumor inhibition rate was not statistically significant, were greater than those of the same group group B3 and C3 group (P lt; 0.01) also were higher than Group D (P lt; 0.01), with a statistically significant. Six weeks after treatment, the pathological prompted B3, C3, D group part of the organization is still visible a small number of tumor cells, while the rest of the treatment group showed no residual tumor cells B1 group surrounding liver tissue damage larger group C2 moderate. After treatment, the B group, especially B1 group of liver function, white blood cells, platelets affect significantly compared to the other groups. The C2 group overall effective than the rest of the treatment group. CONCLUSION: 125 I particles intratumoral implantation combined with TACE treatment of rabbit VX 2 liver transplant tumor can block the tumor blood supply on the one hand, by the local high concentrations of chemotherapy drug treatment of cancer , on the other hand 125 the I particle release of radioactive rays can kill tumor cells, inhibit the reproduction of its regeneration, the two complement each other, significantly better than a single treatment, HCC ideal treatment plan. Single particle activity 0.7mCi more appropriate.
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