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Clinical Research on Children’s Bronchial Asthma in Non-exacerbation Stage Treated with Gu Ben Qu Tan Decoction

Author: MaBingNan
Tutor: WangLiQing
School: Guangzhou University of Traditional Chinese Medicine
Course: Chinese Academy of Pediatrics
Keywords: Gu Ben Qu Tan Decoction Children’s bronchial asthma Non-exace--rbation stage Clinical study
CLC: R272
Type: Master's thesis
Year: 2011
Downloads: 31
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Abstract

ObjectiveBy observing the curative effect of the treatment on children’s bronchial asthma in Non-exacerbation stage, we try to evaluate comprehensively the effect of the treatment, and find it’s clinical advantages and feasibility.MethodAccording with selected standards of the clinical study,95 bronchial asthm children were Included studies, after screening period,57cases of 95 bro--nchial asthm children were divided by the random method into the treated group and the control group. Treated group:This group was given fluticasone aerosol, daily dose is 50 microgram/day; At the same time, this group was given Gu Ben Qu Tan Decoction too. The Gu Ben Qu Tan Decoction is dissolved in 150-250ml warm water, and taked 2 times a day. The control group:This group was given only fluticasone aerosol, daily dose is 100 microgram/day.2 groups were ob--served for 12 weeks. The major end-points:(1) Asthma control level; (2) Determination of lung function(PEF FEV1).The minor end-points:(1) Asthma curative effect that based on symptoms; (2) The days without symptoms; (3) Ease drug (Aerosol albuterol) using frequency; (4)Asthma exacerbation frequency; (5)Safety and adverse reaction. Using SPSS software analyses the datas.Result(1)Four weeks after treatment, asthma control rate of the treated group is 62.9%(17/27), and the control group is 24%(6/25). The comparative dif-ference is statistically significant (P<0.05). Eight and twelve weeks after treatment, asthma control rate of the treated group compared to the control group, the difference is not statistically significant (P>0.05). (2) The FEV1 value and PEF value of the cases of two groups is improved. The difference before and after treatment is significantly (P<0.05). The difference between the the treatment group and the control group is not statistically significant (P >0.05). (3) Four weeks after treatment, Clinical symptom scores of two groups begin to improve, and the difference compared to before treatment is stat-istically significant (P<0.05). Four weeks,8 weeks,12 weeks after tr-eatment, the difference of Clinical symptom scores of two groups is stat-istically significant (P<0.05) at the same period. (4) Four weeks,8 weeks, 12 weeks after treatment, the effective rate of the treated group respectively is 55.6%(15/27)、74.1%(20/27)、85.2%(23/27), and the control group respectively is 24%(6/25)、44%(11/25)、52%(13/25). The difference at the same period between the the treated group and the control group is statistically sign-ificantly (P<0.05). (5) In 12 weeks, the days without symptoms of treated group than control group more about eight days for every case, but the comp--arative difference between two groups is not statistically significant (P >0.05). (6) Ease drug (Aerosol albuterol) using frequency of two groups res-pectively is 1.75+0.45 spray/day and 1.91+0.39 spray/days, the comparative difference is not statistically significant (P>0.05). (7) Asthma exacerbation frequency of two groups all are 2 times. (8) The 57 cases included in the study all don’t happen adverse reactions.ConclusionResearch results show that the Gu Ben Qu Tan Decoction in combination with small-dose ICS can faster make children’s bronchial asthma get control than high-dose ICS, which can reduce inhaled corticosteroids, and can improve cl--inical symptoms related to asthma to improve the quality of life.

Clinical Research on Children’s Bronchial Asthma in Non-exacerbation Stage Treated with Gu Ben Qu Tan Decoction

Abstract

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