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Objective To evaluate the preventive effect of statins on atrial fibrillation . By computer retrieval and electronic databases to get published randomized controlled studies of statins on atrial fibrillation prevention role , after literature screening , literature quality assessment , of literature research design features , the statin group and the control group interventions , statin and control groups in the follow-up period of atrial fibrillation new hair / relapse / recurrence of the number of cases and information extraction , and meta- analysis of the data and concluded the review manager 5.1 statistical software . The results of this meta-analysis of 13 randomized controlled clinical studies were included , the total sample size of 4902 people . 7 Jadad score 3-5 points of high-quality literature , 6 Jadad score 1-2 points low quality literature . Heterogeneity analysis included studies : statistical heterogeneity is large, so the selection of the random effects model Meta-analysis , sensitivity analysis and publication bias estimates . The results showed that : ( 1) statins on cardiac surgery and non- cardiac surgery patients with atrial fibrillation have a significant preventive effect ( cardiac surgery group RR = 0.53, 95 % CI ( 0.41,0.57 ) , P lt ; 0.00001 ; non- cardiac surgery group RR = 0.62,95% CI (0.47,0.81), P = 0.0006); (2) statins new onset atrial fibrillation have a significant preventive effect ( RR = 0.58, 95 % CI ( 0.42,0.80 ) , P = 0.0009 ) ; ( 3 ) statins short-term ( 3 weeks to 1 year ) and long-term use ( more than 1 year ) can significantly reduce the risk of atrial fibrillation ( short-term group, RR = 0.55, 95% CI ( 0.40,0.75 ) , P = 0.0002 ; long-term group RR = 0.63, 95% CI ( 0.46,0.84 ) , P = 0.002 ) ; ( 4 ) he effect of statins on atrial fibrillation recurrence / progress have a preventive effect ( RR = 0.56, 95% CI ( 0.38,0.81 ) , P = 0.002), but the sensitivity analysis of the result in the exclusion of low- quality literature interference was reversed , confirmed the results less reliable ( RR = 0.78, 95% CI ( 0.53,1.17 ) , P = 0.23) . Conclusions (1) statins for heart surgery and non-cardiac surgery patients with atrial fibrillation have statins significantly with preventive effect ; (2) new onset atrial fibrillation have substantially with preventive effect ; (3) he statin drugs short-term ( 3 weeks to 1 year ) use long - term use ( more than one year ) can significantly reduce the risk of atrial fibrillation ; preventive effect of statins on atrial fibrillation recurrence / progression is unclear .
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