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Experimental Study (Uterine Morphology and MDA、 IL-2 Levels in the Serum) on the Rat of Chronic Pelvic Inflam-matory Disease with Different Medication of Qingshizhitong Decoction

Author: WangZuo
Tutor: XiePing
School: Chengdu University of Traditional Chinese Medicine
Course: Chinese Gynecology
Keywords: Clear wet pain soup Different administration method Chronic pelvic inflammatory disease Uterine tissue morphology Malondialdehyde Interleukin-2 Effect and mechanism of
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 37
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Abstract

Purpose:This study were from the national experience of the old Chinese Professor Yang Jialin Qingshizhitong decoction treatment of chronic intermittenta dministration of the treatment of chronic pelvic inflammatory disease vector for thes tudy to observe the Qingshizhitong Decoction intermittent dosing method for the treatment of chronic pelvic inflammatory disease and to explore its role and mechanism,the optimized administration method for clinical safety,effective,economic and rational use of drugs to provide the basis and reference laboratories,and then inherit and carry forward the name of the old traditional Chinese medicineclinical experience and medication characteristics.Methods:This subject adopts the chronic pelvic inflammation of the common pathogenic escherichia coli simulation the chronic pelvic inflammation animal model. From the Angle, aging concentration-response different doses, different drug caused by time for e. coli CIPD model rat uterine anatomy and organizational morphology, serum malondialdehyde (MDA) and interleukin 2 (IL-2) content, (detection methods)Result:1 CPID model group compared with the sham group was significant difference between the high (P<0.01); the CPID drug treatment group and model group were significantly different (P<0.05).2 CPID model group and other groups each group, model group, serum MDA levels were significantly higher than sham operation group, the daughter of film group and the administration of the Qing Tang zhitong groups:sham operation group, the traditional delivery method constants Group and the daughter of film group had highly significant difference (P<0.01), compared with the other groups was significant difference (P<0.05); the administration of the treatment group compared with the sham group no significant difference (P> 0.5.)3 CPID model group and the rest of the group, model group, serum IL-2 were significantly lower than the sham group, the daughter of film group, and the clear soup zhitong groups:one group with the traditional constant delivery method was significantly higher compared Sexual difference (P<0.01), compared with the other groups was significant difference (P<0.05):the administration of the treatment group compared with the sham group no significant difference (P> 0.5).4 Half dose intermittent administration method (intermittent dosing method) and traditional Constant administration method (traditional delivery method), interval constant delivery method, the amount of traditional medication wears a half compared to half the amount of intermittent administration method (intermittent dosing method) the total to Drugs shorten the time, and total daily dose reduced medication, and the CIPD model in rats also have significant therapeutic effect.Conclusion1 The Different administration methods of Qingshizhitong decoction are can remain constant CPDI modeling the normal anatomy of rat uterus, so that side of the uterus of inflammatory swelling, water, significantly reduced hyperemia; can significantly improve the CPID endometrial morphology rats lesions, can be seen on the CPID rat model of pain Qingshizhitong decoction has good therapeutic effect.2 The Different administration methods of Qingshizhitong decoction can obviously reduce the MDA leve lin the blood serum. Therefore the prompt Qingshizhitong decoction possibly through suppresses the lipin peroxidization response to play the anti-SARS role.3 The Different administration methods of Qingshizhitong decoction are can make rats blood concentrations of 2 in IL-significantly increased. Qingshizhitong decoction might through improving the concentration of machine IL-2 strengthen the immune function, and directly or indirectly to strengthen the anti-inflammatory abilities, and achieve the purpose of treatment of chronic pelvic inflammation.4 We can see from the above three points:In this study, wet from the Qingshizhitong decoction anti-inflammatory pain relief directly or indirectly, to protect the rats to the point of view CIPD model:a constant dose of their traditional method (traditional delivery method), interval of constant administration method, dosage half of the traditional administration of law, and intermittent administration of half dose method (intermittent dosing method) rat model can be made directly or indirectly CIPD play and enhance the body fight inflammation and the ability of rats to maintain normal anatomy of the uterus, and significantly improve the endometrial morphology lesions, so as to achieve a therapeutic effect of pelvic inflammatory disease.And intermittent half quantity give medicine method (intermittent dosing method) and traditional constants dosing method (traditional dosing method), interval constants to medicine method, traditional medicine dose halved out-perform dosing method intermittent half quantity dosing method) (batch dosing time is shortened, total daily dose and total to medicine, and reduce the amount of rats with CIPD model has obvious therapeutic effect. And this is what we seek, which USES the smallest dose, the shortest time produced the greatest biological effects of the best medicine method.

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