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Pharmaceutical Research of Fufangchuanbeizhike Granules

Author: ZhangPeiPei
Tutor: GuoLi
School: Chengdu University of Traditional Chinese Medicine
Course: Medicinal Chemistry
Keywords: Vabres Fritillaria Chemical composition Preparation Process Quality standards Stability
CLC: R286
Type: Master's thesis
Year: 2011
Downloads: 101
Quote: 0
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Abstract


Vabres Fritillaria \Chinese medicine theory, under the guidance of the famous Chinese medicine expert Professor Lei Zaiquan clinical experience mainly in order to the fritillary cultivated products vabres mother of pearl square, the physical and chemical properties of the drug, according to the prescription of pharmacological effect, combined with the clinical use of drugs requirements of prescription formulations screening to determine compound Chuanbei cough particles, the preparation process, quality standards, preliminary stability studies, and comparative study based on the chemical composition of the initial system to vabres Fritillaria. The following chemical composition vabres Fritillaria and commonly used clinical the cough Jiapin Sumbe comprehensive comparison study: ① using thin-layer chromatography overall chemical composition analysis; (2) using acid dyes - UV-visible spectrophotometry both Fritillaria The total alkaloid content and comparative analysis; ③ by HPLC-ELSD method the Determination of of different Fritillaria peimine and peiminine content, were analyzed and compared; ④ research vabres fritillaria and sombe of mother HPLC-ELSD fingerprints; (5) phenol - sulfuric acid method for the determination of the amount of in different Fritillaria acid before and after hydrolysis of the polysaccharide, as a basis to conduct of different Fritillaria non Alkaloids preliminary analysis. The compound Chuanbei cough particles herbs processing by vabres mother of pearl, orange peel, skullcap made use of modern processing technology based on its physical and chemical properties of the medicinal ingredient, and clinical applications require comprehensive survey by the multi-index screening, and ultimately determine the process parameters the compound Chuanbei cough particles. After pilot production verification, the process is reasonable, stable and viable. Standards of quality standards of some of the major raw materials of quality standards and the quality of the preparations. Herbs Pieces of feeding raw materials quality standards in accordance with the Chinese Pharmacopoeia (2010 edition) requires various tests. Pharmacopoeia requirements preparation quality standards in the production of pilot batches of samples were a general examination of the particles, the qualitative identification, HPLC method for simultaneous determination of hesperidin and baicalin content in order to control the quality of the sample. The the reference substance vabres peimine Fritillaria Compound TLC method; based reference drug Aster and one hundred the Aster one hundred TLC method; Compound Determination of hesperidin and baicalin content in the sample, multiple indicator control. The batches in the test sample measurement results were compared, the transfer rate of greater than 50%, indicating that fewer losses in the production process. Pilot sample retention samples at room temperature observed in three batches, the results display compound Chuanbei cough particles stability is good. Particles research on compound Chuanbei cough can expand of clinical cough and medicinal resources, vigorously the cultivation cultivation vabres Fritillaria provide market for the Sichuan disaster reconstruction, disaster areas to help people rebuild their beautiful homeland.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > In drugs
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