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The Bioactivity and Marine Antifouling Performance of Four Kinds of Benzisothiazolones
Author: ZhengHongHui
Tutor: LinQiang;YangJianXin
School: Hainan University
Course: Biochemical Engineering
Keywords: Benzo- isothiazolin- ketone Synthesis Bioassay
CLC: O626
Type: Master's thesis
Year: 2011
Downloads: 98
Quote: 2
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Abstract
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Benzo- isothiazolin- ketone derivatives as a fungicide widely used in agriculture , industry, medicine and other industries , this paper mainly studied as a green antifouling agent on algae , bacteria , fungi, marine bacteria inhibited the synthesis of the laboratory four benzisothiazole -ketone compounds algal experiments , suppressing bacterial experiments fungistatically experiments , inhibition experiments and marine antifouling marine bacteria experiments to explore the structure and biological activity relationship studies and test the structure of the compound is as follows: ( 1) 2 - ( benzo- isothiazolin -3 - one-2 - yl ) carboxylic acid ester ( 2) 2 - (2 - substituted phenoxy acetyl)- benzisothiazol -3 - ketones ( 3 ) N- substituted phenyl-2 - ( benzo- isothiazolin -3 - one-2 - yl ) carboxamides according benzo isothiazolin ketones mechanisms and biological activity were designed and synthesized on the basis of four unreported novel benzo isothiazolin derivatives and studied their biological activity. The structure of 2 - ( benzo- isothiazolin -3 - one-2 - yl ) carboxylic acid ester compound. By elemental analysis, nuclear magnetic resonance , infrared spectroscopy and other means to determine its structure . Bioassay results showed that the compounds inhibit the growth of algae on the activity of the ball Isochrysis highest activity on the Asian heart-shaped flat minimum activity of algae , Chlorella pyrenoidosa activity centered. Most of the compounds inhibit the activity of the test species . Escherichia coli, Staphylococcus aureus, gummy stem blight pathogen , amines cell anthrax Chains Aeromonas , Vibrio alginolyticus HN07005, alginolyticus HN08201, alginolyticus HN08807 have shown good antibacterial properties . Thesis final choice bioactive compounds were higher pollution at sea experimental results are consistent with the biological activity tests .
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CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Heterocyclic compounds
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