Dissertation > Excellent graduate degree dissertation topics show

The Function of Fuantang Treating POI in Mice Model and the Mechanism Related with Mast Cell

Author: SunChuanXin
Tutor: QuMingYang
School: Dalian Medical University
Course: Traditional Chinese Medicine
Keywords: fuantang postoperativeilues mast cell degranulation inflammation
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 0
Quote: 0
Read: Download Dissertation

Abstract


PURPOSE:To explore the function of fuantang which may relief the symptoms of POI and the mechanism related with mast cell.METHODS:【Model】The mice were anesthesiaed with chloralic hydras,then opened the peritoneal cavity.The small intestine was carefully exteriorised from the distal duodenum until the cecum and gently manipulated for 5 min using sterile moist to establish POI model.【Group】60 mice were selected and devided into 3 groups(n=20)randomly. A:matched group,B:model group and C: chinese medicine group.A1,B1 and C1 group may show the expression of HIS ,tryptase and the accountant and degranulation of mast cell .A2,B2 and C2 group may show the carbon powder moving rate and the activation of mpo after 6 hours of surgery.RESULTS:①The expression of tryptase in B1 (0.084±0.039)was much higher than C1(0.061±0.015)(P<0.01).The expression of tryptase in C1 was much higher than A1(0.045±0.0165)(P<0.01).②The expression of HIS of B1 (7.47±1.79)was much higher than C1. (5.94±1.42)(P<0.01).The expression of HIS in C1 had no difference with A1(4.96±1.3)(P>0.05).③A1:The degranulation phenomenon in mast cell can not been observed.B1:The degranulation phenomenon in mast cell can be obviously observed.C1:The degranularion phenomenon can be observed a little weeker than B1.④The activation of MPO in C2(3.9±0.96) was much lower than B2(7.10± 0.72)(P<0.01),but was a little higher than A2(1.57±0.14)(P<0.05).⑤The carbon powder moving rate show that C2(52.84±7.91) was much higher than B2(30.17±7.25)(P<0.01),but lower than A2(58.11±5.13)(P<0.05).CONCLUSIONS:①Fuantang may raise the carbon powder moving rate of mice model,improve intestinal peristalsis,relief the symptoms of POI.②Fuantang may inhaibit the inflammation via reducing the degranulation of mast cell in mice model of POI.③Inhabiting the inflammation induced by the degranulation of mast cell is an important mechanism for fuantang treating POI.

Related Dissertations

  1. The Effect and Mechanism of p38MAPK Inhibitor CBS3830 on Intimal Hyperplasia in Autogenous Vein Grafts of Diabetic Rats,R587.1
  2. The Experimental Research of RNAi Technology Inhibiting Respiratory Syncytial Virus,R725.6
  3. Correlative Study on Plasma Level of Resistin in Patients with Coronary Atherosclerosis Disease,R541.4
  4. Effects of Blockade of IL-17 in Already Established Asthma of BALB/c Mice,R562.25
  5. The Function and Mechanism of Endoplasmic Reticulum Stress Pre-treatment on the Improvement of Renal Tolerance Toward Ischemia-reperfusion Injury,R692.5
  6. The Roles of Spinal Cord Glia in Bee Venom-induced Nociception and Inflammation in Concious Rats,R741
  7. LPS activation of complement on endothelial cells and the inhibition of complement on LPS- induced acute lung injury,R563.8
  8. The Effects of Low-arsenic Exposure in Drinking Water on Cardiovascular System and the Function of Dietary Factors,R151
  9. Rhizoma Coptidis Inhibits LPS-induced MCP-1 Production in Murine Macrophages,R285
  10. Comperative Experiment on the Toxicity of Particulate Matter from Different Cities,R114
  11. Low-dose Methotrexate Suppresses Liver Inflammation Via Downregulating iNOS Expression of Macrophages,R363
  12. The Effect of Mesenteric Lymphatic Ducts Drainage on Inflammatory Resolution of Acute Lung Injury After Intestinal Ischemia-Reperfusion in Rats,R563.8
  13. Lipoxin A4 Supresses Prostate Cancer Cells Via Blocking the Activation of Macrophages,R737.25
  14. Aspirin-triggered Lipoxin Inhibit the Inflammatory Response Induced by Lipopolysaccharide in Primary Astrocytes,R965
  15. Effects of Aspirin-Triggered Lipoxin on the Interleukin -6 Induced Inflammatory Response in Astrocytes,R965
  16. Anti-inflammatory effect of fusion protein anticoagulant dual function of TAP-SSL5,R543.5
  17. Antlers disc anti-inflammatory effects of extracts,R285.5
  18. The Effects of Rosiglitazone and Prednisone on the Expression of FIZZ1 in the Pulmonary Fibrosis Induced by Blemycin,R965
  19. Effect of M3 Muscarinic Receptor Antagonist Bencycloquidium Bromide on Airway Inflammarion and Remodeling in Mice,R965
  20. The Expression and Regulation of Hbd-2 in Salivary Gland Tumor and Inflammation,R739.8

CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology
© 2012 www.DissertationTopic.Net  Mobile