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Objective: By studying the variability in lung function, peripheral blood inflammatory indicators and Gensini score between chronic obstructive pulmonary disease(COPD)combined coronary atherosclerotic patients , and patients which have coronary atherosclerotic without COPD,this article is to investigate the the impact of COPD on coronary atherosclerotic.Methods: Coronary angiography and spirometry were performed in 62 subjects. Accordingly, we divided the all subjects into three groups, including 20 COPD-free patients with coronary atherosclerotic、26 COPD patients which have coronary atherosclerotic and 16 healthy controls, and determined levels of total serum cholesterol, high-density lipoprotein(HDL), low-density lipoprotein, triglyceride, and apolipoprotein AI and B; levels of fasting plasma glucose; levels of plasma fibrinogen; levels of peripheral blood leukocyte, neutrophil, monocyte, lymphocyte and platelet counts, among them, Inflammatory indicators include: plasma fibrinogen; platelet leukocyte, neutrophil, monocyte, and lymphocyte counts. Lung function indicators include: the percentage of predicted forced expiratory volume in 1 second (FEV1%pre), FEV1/FVC (forced vital capacity, FVC) ratio. COPD patients combined coronary atherosclerotic were classified as mild in 6 cases, moderate in 16 cases, severe or more in 4 cases by COPD severity. The Gensini score is also needed to be recorded after coronary angiography, to evaluate the severity of coronary atherosclerotic. By SPSS software, variability was assessed among three groups in inflammatory factors, lung function indicators and Gensini score; relationships were assessed between the Gensini score and Lung function indicators, the Gensini score and inflammatory indicators. Stepwise regression analysis: the impact of indicators which had the relationship with Gensini score on Gensini score. Results: Compared with normal control group,peripheral blood leukocyte, neutrophil, and monocyte count was respectively significantly higher, (P<0.05), FEV1%pre decreased significantly (P<0.05)in COPD combined coronary atherosclerotic group; The coronary atherosclerotic group had higher leukocytes, neutrophils than normal control group (P <0.05), and had lower FEV1%pre.Compared with coronary atherosclerotic group, in COPD combined coronary atherosclerotic group peripheral blood leukocyte, neutrophil, and monocyte count was respectively significantly higher (P<0.05), FEV1%pre decreased significantly (P<0.05),and Gensini score was significantly higher (P<0.05).In COPD combined coronary atherosclerotic group, Gensini score was positively correlated with peripheral blood leukocyte and monocyte count (respectively, r=0.438,P<0.05; r = 0.421, P <0.05) ; Gensini score was negatively correlated with FEV1 %pre (respectively, r = - 0.668,P<0.05); By multie regression analysis only FEV1%pre was correlated with Gensini sore( Y =83.535-0.675×FEV1%pre).Conclution: Airflow limitation is a risk factor for coronary atherosclerosis. The reason is that Inflammatory reaction of COPD may worsen the degree of coronary atherosclerosis.
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