Dissertation > Excellent graduate degree dissertation topics show

The Effect of Mild Hypothermia Combined with TP-5 to T Lymphocyte Subsets and Prognosis of Patients with Severe Traumatic Brain Injur

Author: XuDaWei
Tutor: LinYuanQuan
School: Zunyi Medical College,
Course: Neurosurgery
Keywords: mild hypothermia TP-5 severe traumatic brain injury T lymphocyte subsets prognosis
CLC: R651.15
Type: Master's thesis
Year: 2011
Downloads: 0
Quote: 0
Read: Download Dissertation

Abstract


Objective:To study the effect of mild hypothermia combined with TP-5 to T lymphocyte subsets and prognosis of patients with severe traumatic brain injury. Metheds:All 42 patients with severe traumatic brain injury (Glasgow coma scale score of 8 or less on admission) were randomly divided into the mild hypothermia combined with TP-5 group [experimental group,22 case] and hypothermic group [control group (一),20 case]. Meantime, giving TP-5 with intravenous drop infusion and conventional therapy, hypothermia was induced within 24 hours of injury.The therapeutic regimen of control group (一) was the same with experimental group except for TP-5.Experimental group and control group (一) were detected with T lymphocyte subsets (CD3+、CD4+、CD8+、CD4+/CD8+) of venous blood on days 1、3、7、14 post injury by flow cytometry. The healthy check-up [control group (二),18 case] were detected with T lymphocyte subsets (CD3+、CD4+、CD8+、CD4+/CD8+)of venous blood by flow cytometry.T lymphocyte subsets were compared between the three groups. Hospital onset of infection and the prognosis of the patients were observed between experimental group and control group(一).Results:On days 1 post injury, T lymphocyte subsets(CD3+、CD4+、CD8+、CD4+/CD8+) didnt have difference between experimental group and control group(一); T lymphocyte subsets(CD3+、CD4+、CD4+/CD8+) have difference between experimental group and control group(二); T lymphocyte subsets(CD3+、CD4+、CD4+/CD8+) have difference between control group(一) and control group(二). On days 3 post injury, T lymphocyte subsets(CD4+、CD4+/CD8+)have difference between experimental group and control group(一); T lymphocyte subsets(CD3+、CD4+、CD4+/CD8+)have difference between experimental group and control group (二); T lymphocyte subsets(CD3+、CD4+、CD4+/CD8+)have difference between control group(一) and control group(二).On days 7 post injury, T lymphocyte subsets(CD3+、CD4+、CD4+/CD8+) have difference between experimental group and control group(-); T lymphocyte subsets(CD3+、CD4+、CD8+) didn t have difference between experimental group and control group(二); T lymphocyte subsets(CD3+、CD4+、CD4+/CD8+) have difference between control group(一) and control group(二).On days 14 post injury, T lymphocyte subsets(CD3+、CD4+、CD4+/CD8+) have difference between experimental group and control group (一); T lymphocyte Tsubsets(CD3+、CD4+、CD8+、CD4+/CD8+)didn t have difference between experimental group and control group(二); T lymphocyte subsets(CD4+、CD4+/CD8+)have difference between control group(一) and control group(二).There was no difference between experimental group and control group(一) in the increased ICP. There were difference between experimental group and control group(一)in hospital onset of infection. There were difference between experimental group and control group(一) in the prognosis of patients.Conclusion:Mild hypothermia combined with TP-5 could improve T lymphocyte subsets of patients with severe traumatic brain injury, decrease hospital onset of infection rate and improve the prognosis of patients. Mild hypothermia combined with TP-5 can was safe and effective to patient and it has potential clinical application.

Related Dissertations

  1. Software Design of Muliparameter On-Line Monitoring System in Water-Quality,TP3
  2. The Value of Ultrasonic Elastography in the Diagnosis and Prognosis of Breast Lesions,R445.1
  3. The Clinical Significance of T Cell Subgroups and NK Cell’s Expression Level in Diffuse Large B-cell Lymphoma Patients,R733.1
  4. The Study of Clinical Prognostic Factors in Nasopharyngeal Carcinoma after Intensity Modulated Radiation Therapy,R739.63
  5. The Relationship between TLR4 Protein Expression of Peripheral Blood Monocytes and the Pathogenetic Condition and Prognosis in Patients with Acute Coronary Syndrome,R541.4
  6. Clinical Analysis of 11 Cases of Primary Breast Lymphoma,R737.9
  7. Recurrent Ovarian Cancer Surgery Again with Surial Analysis of Relevant Factors,R737.31
  8. Cloning and Expression of Novel β-Glucosidase Genes from Rhizopus Stolonifer Var. Reflexus,Q78
  9. Psoriasis vulgaris in different stages and card Hou T lymphocyte subsets,R275.9
  10. Color Doppler to Determine Perinatal Outcome of Clinical Value,R714.7
  11. Research of Risk Factors, Predictors and Prevention of Pancreatic Fistula after Pancreatoduodenectomy,R656
  12. The Feasibility of the Immunohistochemistry Classification to Predicting Prognosis in Breast Cancer,R737.9
  13. Analysis of Clinial and Patholgoic Characteristics between the Han and the Uygur Patients with Triple-negative Breast Cancer,R737.9
  14. Clinical Signifinance of Combined Detection of Tumor Markers in Breast Cancer,R737.9
  15. Cervical Cancer Patients Clinical Prognostic Factor Analysis (72 Cases Analysis Attached),R737.33
  16. Analysis of the Risk Factors Influencing the Morbidity and the Prognosis of Hepatic Encephalopathy,R747.9
  17. The Expression and Clinical Significance of Ercc1 in Human Gastric Cancer,R735.2
  18. Rare Thyroid Carcinoma: a Retrospective Analysis of 42 Cases,R736.1
  19. Heart rate variability and coronary artery disease and prognosis of acute myocardial infarction,R541.4
  20. Underwent emergency surgery and PCI in STEMI patients with cardiogenic shock, the clinical characteristics and prognosis,R542.22

CLC: > Medicine, health > Surgery > Of surgery > Head and Neurosurgery > Brain > Traumatic brain injury
© 2012 www.DissertationTopic.Net  Mobile