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Pain capsule preparation process and pharmaceutical raw materials ultrafine grinding of

Author: GuYu
Tutor: WangYuRong
School: Beijing University of Traditional Chinese Medicine
Course: Chinese medicine pharmacy
Keywords: Angelica dahurica Chuanxiong Physical and chemical properties Super fine crush Tongning Capsules
CLC: TQ461
Type: Master's thesis
Year: 2009
Downloads: 114
Quote: 0
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Abstract


Objective:The Tongning Capsule comes from clinical experience prescription,with the effectiveness of dispel cold and promoting blood circulation to remove meridian obstruction,be used for the treatment of anemofrigid headache and gore retardation. according to herbal medicine property and clinical characteristics of nature,this study try to use the superfine comminution technique to deal with the original medicine,and directly use for the preparation of Tongning Capsule,to sum up the applicability of superfine powder which contain volatile and heat-sensitive components by studying physics,chemistry and other the nature characteristics of Angelica dahurica a nd Chuanxiong’s superfine powder.Methods:1) Choose the content of two kinds of coumarin and powder size pieces as target to select optimal ambient ternperature super fine crush technics of Angelica dahurica,and investigate physical and chemical characteristic of Angelica dahurica super fine powder preliminary in addition.2) Deal Chuanxiong at ambient temperature and low temperature vibration crush treatment separately,then compare their impact of the heat-sensitive and volatile components,use the content of ferulic acid and volatile oil as the target to select optimal superfine comminution technique, study physical,chemical and dissolution characteristic of Chuanxiong superfine powder preliminary in addition.3) The volatile of Breviscapus was included byβ-cyclodextrin.4) Tongning capsules were made after the process of the pro-rata mix of Angelica dahurica、Chuanxiong s uper fine powder and cyclodextrin inclusion compound of Breviscapus,made of particles,drying and packaging.5) The study on quality specification:By using TLC made qualitative analysis on each constitute of Tongning capsule;By using HPLC made quantitative analysis on imperatorin.Results:1) The size and the target composition of Angelica dahurica are the best after 15 minutes ambient temperature vibrate crush.2) Compare with ambient temperature vibrate crush,low temperature can inhibit the bss of volatile oil in Chuanxiong and have no change of heat-sensitive ingredients.3) Set up the quality standards of Tongning capsule,methodological study shows that the precision,stability, reproducibility and recovery rate are in line with the requirements,experimental data is stable and reliable.Conclusion:The physics and chemistry characteristic of Angelica dahurica and Chuanxiong stability which were deal with ambient temperature vibration crush andlow-temperature vibrate crush respectively;and they are superior than conventional powder in dissolution and thermal extraction aspect.The powder mixture has good formability.Tongning capsule is accord with the Chinese Pharmacopoeia requirements,quality and crafts control.

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