Dissertation > Excellent graduate degree dissertation topics show

Synthesis, Structure Characterization and Biological Activities of 5（3）-Ary1-1H-3（5）-Substituted Pyrazoly1 Hydrazones

Author: ZhouGuangHua
Tutor: AnYue；XingYongHeng
School: Liaoning Normal University
Course: Organic Chemistry
Keywords: pyrazole derivatives hydrazones isomer crystal structure synthesis
CLC: O626.2
Type: Master's thesis
Year: 2008
Downloads: 133
Quote: 0
Read: Download Dissertation

Abstract


Much attention has been paid to the study on the pyrazole derivatives due to their good biological activities such as effectively, low toxicity and the multi-changeable substituted groups on the pyrazole ring. On the other hand, hydrazones compounds have also attracted more and more attention according to their excellent biological and medical activities.In this paper, 4-substituted acetophenone and diethyl oxalate were used as the starting materials, based on the methods of Claisen condensation, Knorr cyclization, amination of the ester, then reacted with the aromatic aldehydes, the two excellent biological groups discussed above-pyrazole and hydrazones, were connected together organically. 30 target compounds and 9 related intermediates were obtained, in which 20 target compounds and 4 intermediates are new compounds that have not yet been reported in the literatures.All the target compounds and intermediates were characterized by IR, NMR. A representative compound was characterized in the 2D and difference thermal NMR test for further studying the structures of the target compounds and come to the conclusion that the trans isomer is the main component in the target compounds. In order to confirm the structures of the obtained organic compounds, three organic crystals of the target compounds, two new coordination compounds and a organic crystal from the reaction of the intermediates and the transition metal ion(Cu2+) were obtained and their structures were characterized by X-ray single crystal diffraction measurement.Besides, primary biological activity experiments have been done to all the target compounds in order to study their effects on the germination process of mung bean. The preliminary results show that the target compounds have the effect of accelerating the germination process of mung bean when there are not any substituted groups or the substituted group is methyloxyl in the phenyl ring connecting to the pyrazole. However, when it is substituted by a nitro group in the phenyl ring, the target compounds have inhibiting effect on the germination process of mung bean.

Related Dissertations

  1. Studies on the Synthesis and Technology of Dipentaerythritol and Its Derivative,TQ223.164
  2. Synthesis and Characterization on Semi-Aromatic Polyamides Containing Benzoxazole Units,O633.5
  3. Hydrothermal Synthesis of Oxide Hollow Spheres,TB383.4
  4. Video Coding Research Based on Texture Characteristics,TP391.41
  5. Poetic alienation : graphics,J506
  6. Urothermal Synthesis, Structure and Characterization of Functional Coordination Polymers,O631.3
  7. The Total Synthesis of a Flavonoid Glycoside Apigenin-7-O-β-D-glucuronide,R284.1
  8. Atovaquone analogues Design, Synthesis and antitumor activity of,R914
  9. Synthesis and Seperation of 1,1’-binaphthol,O625.3
  10. Flexible,rigid,Synthesis and characterization of mixed ligand complexes,O621.1
  11. Synthesis and Performance Study of Bisphenol AP-based Polybenzoxazines,TQ320.1
  12. Study on the Synthetic Process of Vat Pink R,TQ616.2
  13. Study on the Mechanism of Night Temperature to Grain Filling of Inferior in Rice,S511
  14. Gold-catalyzed Addition Reaction of Sulfonates and Alkynes and Study of Synthesis and Bioactivity of (E)-3-phenyl-substituted Acrylic Acids,R914
  15. Synthesis and Identification of P22/P221 Polypeptides of IBDV Ligand Epitope and Screening CEF Library,S852.65
  16. The Properties and Synthesis of Photochromic Indole-Substituted Fulgides,O626
  17. Curing Mechanism and Properties of Fluorenyl Epoxy Resin,TQ323.5
  18. Study on Antioxidant Activities and Lipase-catalyzed Transesterification of Lard to Produce L-ascorbyl Fatty Acid Esters,TS202.3
  19. Syntheses of Novelbenzopyran Compounds Containing Fluorine and Induced Resistance to TMV,S435.72
  20. Research on the Physiology Mechanism of Grain Filling of inferior Grain during Day and Night Chemical Regulations,S511
  21. Molecular Biological Characteristics of Multiple Porcine Fc Gamma RⅡB Sub-isoforms Generated by Alternative Splicing,S828

CLC: > Mathematical sciences and chemical > Chemistry > Organic Chemistry > Heterocyclic compounds > Containing five pairs or more different atoms of heterocyclic
© 2012 www.DissertationTopic.Net  Mobile