Dissertation > Excellent graduate degree dissertation topics show

The Change and Significance of MMP-9 in the Patient of Fetal Growth Restriction

Author: CaoMin
Tutor: ZhangXueQin;ZhangXiaoQin;YangLiHua
School: Kunming Medical College
Course: Obstetrics and Gynaecology
Keywords: Matrix metalloproteinase-9 Shallow placental implantation Fetal growth restriction Solid phase sandwich enzyme-linked immunosorbent assay
CLC: R714.5
Type: Master's thesis
Year: 2009
Downloads: 45
Quote: 0
Read: Download Dissertation

Abstract


Objective: To detect fetal growth restriction ((fetal growth restriction, FGR) venous blood of pregnant women and their newborns umbilical cord blood of matrix metalloproteinase -9 ( matrix metalloproteinases - 9 , MMP - 9 ) levels to explore MMP-9 in fetal growth restriction pathogenesis . methods: solid-phase sandwich enzyme-linked immunosorbent assay (ELISA method) were detected 20 cases of fetal growth restricted venous blood of pregnant women and their newborns umbilical venous blood MMP -9 level ( FGR group ) , 20 cases of normal full-term pregnancy pregnant women cubital vein and their newborns umbilical cord blood ( normal group ) level of MMP-9 in the processing of data obtained using SPSS 13.0 statistical package results : ( 1 ) FGR group maternal venous blood level of MMP-9 ( 103.00 ± 38.71 ) ng / ml , the normal group of pregnant women cubital vein MMP-9 level ( 196.60 ± 78.91 ) ng / ml , FGR group of pregnant women cubital vein blood MMP-9 levels below the normal group , the difference was significant ( P lt ; 0.001 ) ( 2 ) FGR group newborn's umbilical cord blood level of MMP-9 ( 80.30 ± 30.47 ) ng / ml , normal group newborn's umbilical cord blood MMP-9 level ( 153.80 ± 83.62 ) ng / ml , the FGR group neonatal umbilical cord blood level of MMP-9 is lower than that of the normal group , the difference was statistically significant ( P lt ; 0.05 ) ( 3 ) FGR group , MMP-9 water in the venous blood of pregnant women in the normal group was higher than that in the umbilical venous blood MMP-9 level ( P lt ; 0.05 , P lt ; 0.05 ) , and the FGR group normal group , MMP-9 levels were in the venous blood of pregnant women and newborn umbilical cord blood in the MMP-9 level was positively correlated ( r = 0.593 , r = 0.624 ) . ( 4 ) the FGR group in pregnant women cubital vein and MMP-9 levels were in the neonatal umbilical cord blood and neonatal weight was positively correlated (r = 0.476, P lt; 0.05; r = 0.567, P lt; 0.05), venous blood of pregnant women and newborns in the normal group umbilical cord blood in MMP-9 levels were no correlation between birth weight (P gt; 0.05, P gt; 0.05). conclusions: MMP- cubital vein in the umbilical cord blood of pregnant women with fetal growth restriction 9 levels were significantly decreased MMP - 9 level and fetal growth restricted newborn's birth weight was positively correlated with normal birth weight of the newborn was no correlation between MMP - 9 in the fetal growth restriction occurred in the development from an important role , is expected to be one of the new indicators as a prediction of fetal growth restriction .

Related Dissertations

  1. Roles of MMP-7 and Lysozyme in the Pathogenesis of Ulcerative Colitis Induced by DSS in Balb/c Mice,S858.91
  2. The Expression of MMP-2、 VEGF and Ki-67 and Human Glioma Grade,R739.41
  3. Study on the Expression and Correlation of Metallothionein and Matrix Metalloproteinase-2 in Non-small Cell Lung Cancer,R734.2
  4. Studies on the Growth and Transfer Behaviour of Hca-F Cell and Immunomodulatory of fucoidan,R285.5
  5. Effect of Etiasa on the Expression of MMP-2 and TNF-α in Rat Model of Ulcerative Colitis,R574.62
  6. Meningiomas and MMP-9, VEGF expression and tumor angiogenesis and recurrence,R739.45
  7. The Research on MMP-10 Expressing in Human Benign and Malignant Breast Tissue,R737.9
  8. Expressions of Matrix Metalloproteinase-3 and Matrix Metalloproteinase-9 in the Serum and Sacroiliac Joint of Spondyloarthropathy,R593.2
  9. Protective Effect of Mangiferin on Kidney in Diabetic Rats,R285.5
  10. Establishment Andapplication of Two in Vitro Screening Methods for Cosmetic Additives with Anti-aging Effect,TQ658
  11. The Expression of Smad4, MMP-9 in Colorectal Carcinoma and Their Effect on the Tumor Angiogenesis and Metastasis,R735.3
  12. The Initial Study of Silence EC9706 Cells CD147 Expression,R735.1
  13. The Effects of Bevacizumab on Corneal Neovascularization in a Rat Model and Its Correlation Between the Drugs Concentration and Effects,R965
  14. The Approach of Anti-tumor Mechanism of the Combination of Zedoary Turmeric Oil and Thalidomide in Lewis Transplantation Tumor,R734.2
  15. Studying the Role of CaMKⅡδ Isozyme in Myocardial Fibrosis and Its Molecule Mechanism,R542.23
  16. The Effect and Mechanism of Recombinant Human Endostatin in Proliferation and the Capacity of Invasion of Cervical Cancer Hela Cells,R96
  17. The Protective Effects of Low-dose Hydrocortisone on Sepsis-induced Lung Injury in Rats Model is by Up-regulation Expression of the Glucocorticoid Receptor Alpha Isoform,R459.7
  18. Correlated Research on Roles of GDNF and Its Receptor on Perineural Invasion of ACC,R739.8
  19. The Expression and Significance of TNF-α and MMP-1 in Middle Ear Cholesteatoma,R764
  20. The Study on the Expression of MMP-2 and MMP-9 in the Diabetic Rats Retina,R774.1
  21. STAT3 Molecular Signaling Pathway in Suppression of Bisdemethoxycurcumin on Human Ovarian Cancer SKOV-3 Cells,R737.31

CLC: > Medicine, health > Obstetrics and Gynaecology > Obstetrics > Fetus
© 2012 www.DissertationTopic.Net  Mobile