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Insomnia is a disease more common in modern life, mainly as difficulty falling asleep, easy to wake up, wake up early, or poor quality sleep or sleep time was significantly reduced, or several combination of. Western medicine treatment stressed timing rest and rational use of sedative-hypnotic drugs, clinical preferred to take sleeping pills, the drug hypnosis faster, but there are considerable side effects, drug resistance, addiction vulnerability, so patients with this often harbor fear. The basic rule of TCM to Shugan Jieyu, Xiaotan, Sanjie treatment of the disease, and more able to achieve the purpose of tackling the problem. In this paper many years of clinical practice summarizing experience side made use of modern scientific and technological means granules, for the treatment of phlegm scrambling Insomnia the new dialectical thinking and treatment to the clinical treatment of insomnia, in order to better to meet the market demand. The literature review TCM insomnia, etiology and pathogenesis, classification and rule is the understanding of Western medicine on insomnia and conquer, Chinese and Western clinical medicine in three areas discussed. Test part of the pharmacy part of the preparation process of research, quality standards for research and in vivo drug-related research. Study on Preparation Technology: by behavioral pharmacology test, the best prescription; using orthogonal test process optimization, optimum extraction conditions were purified by water extraction and alcohol precipitation, the theoretical basis of the prescription by the preparation process design and herbs nature determine the selection of granules, the 3 flavored herbs in the other to do the following screening process: Sophora such as herbs with 12 times the amount of water extracted three times, each time 0.5h, filtered, concentrated decoction is concentrated to the relative density of 1.05 to 1.10 (50 ° C test), adding ethanol to the alcohol concentration of 60%, allowed to stand overnight, filtration, recovery of ethanol, concentrated, and dried under reduced pressure. Preferred granules dry extract molding process. Quality standards: qualitative identification and application of granules flavescens by TLC HPLC determination of matrine and oxymatrine content quality standards. Vivo drug-related research: comparison fingerprinting obtained the main source of medicines peaks and changes; granules determined by HPLC peak time, peak to be studies in rats and mass spectrometry to identify the blood collection time; through LC- MS initially speculated that the basic information out of the blood components. Compound matrine soothe the nerves particles above study to determine the best extraction process and the preparation process to develop quality standards, preliminary in vivo drug metabolism studies, the basic information of the ingredients into the blood, and laid a solid for the further study of the late basis.
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