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Chinese medicine preventive study of femoral head necrosis

Author: WangDongXue
Tutor: MaLi
School: Beijing University of Traditional Chinese Medicine
Course: Integrative Medicine Internal Medicine
Keywords: Chinese medicine Femoral head necrosis Prevention
CLC: R274.9
Type: Master's thesis
Year: 2009
Downloads: 134
Quote: 0
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Abstract

This paper studies the traditional Chinese medicine on the preventive effect of femoral head necrosis (SANFH), is divided into the following three parts. The first part of the literature review, review of Chinese medicine research SANFH progress. Dialectical theory of governance summarizes many physicians view that virtual, stasis two pathogenesis implement this disease has always been the treatment of kidney strong emphasis on bone and blood circulation. Experimental studies have found that Chinese medicine can improve blood state, protect vascular endothelial promote sex hormone secretion and regulation of bone metabolism in a variety of ways such as prevention of the occurrence of SANFH. The many clinical experience side studies have shown that the exact effect of Traditional Chinese Medicine the SANFH the early stages of treatment. In addition, Chinese medicine to prevent the disease also made some progress. Chinese medicine in the prevention and treatment of SANFH has a large advantage. The second part of the clinical study, the purpose of: systemic lupus erythematosus (SLE), concurrent femoral head necrosis (of ANFH), risk factors, clearly hormone pathogenic role of femoral head necrosis. Methods: Retrospective analysis of the Ministry of Health in Japan Friendship Hospital inpatient treatment of 461 cases of SLE, 32 cases of merger ANFH of patients with 64 cases non-ANFH patients, logistic regression analysis to extract relevant clinical information. Results: of hospitalized patients ANFH in 461 patients with SLE incidence of 6.94%, accounted for 65.63% of the cases of SLE disease duration of 3 years ANFH; cutaneous vasculitis, elevated platelet elevated fibrinogen (Fib), low-density elevated lipoprotein cholesterol (LDL-C) and the initial dose of oral corticosteroids and a half of the cumulative amount of SLE the merger between ANFH patients with SLE non-ANFH patients have more significant differences (P <0.05); age , no correlation (P> 0.05); multi-factor analysis of gender, disease duration, Raynaud's phenomenon, mouth ulcers, renal involvement, high blood pressure, anemia, ACL positive, with or without line hormone shock aspects ANFH of the occurrence of cutaneous vasculitis and hormones the semi-annual accumulation is SLE ANFH, independent risk factors (P <0.05). Conclusion: in the SLE course of 3 years ANFH the dangerous relatively high; after high-dose hormone therapy and skin ulcers, gangrene and skin vasculitis the SLE concurrent ANFH, an independent risk factor; platelets, FIB, LDL-C SLE patients with elevated the concurrent ANFH risk, these abnormal laboratory parameters may be associated with the application of the hormone. The third part of clinical research, the purpose of: observation and evaluation of proprietary Chinese medicines Xianlinggubao the capsule SANFH clinical preventive effect effectiveness and safety. Methods: A double-blind, randomized, placebo-controlled method is expected that the use of high-dose hormone therapy in patients selected according to the inclusion and exclusion criteria were randomly divided into two groups, the treatment group took the capsule of Xianlinggubao, the use of the control group placebo observe the clinical conditions of the patients, hip MRI and blood, urine, liver and kidney function, blood coagulation and fibrinolysis laboratory test results. Results: A total of 25 patients were enrolled in the treatment group 16 cases, 9 cases of the control group, two groups in terms of age, gender was no significant difference (P> 0.05); Harris hip score of all patients during the study period are excellent, the treatment group and the control group were not found the hip MRI abnormalities; the Fib average of 12 weeks and 24 weeks of treatment group compared with the control group, with significant difference (P <0.05); research observation was not found in patients treated with significant adverse reactions occur. Conclusion: This medicine may be part of the improvement of hormone treatment of patients with coagulation and fibrinolysis, with an estimated ischemia on to play a role in delaying the femoral head microcirculation, prevention of bone necrosis occurs to some extent. Due to the small number of cases of clinical observation, not yet XLGB capsules in preventing SANFH a significant effect. In addition, the drug in clinical applications with better security.

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