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The Effect of Berberine Hydrochloride on the Levels of Serum CRP and Complement C3, C4 in Patients with Acute Cerebral Infarction

Author: LiuMin
Tutor: CaoHong
School: Dalian Medical University
Course: Neurology
Keywords: Acute cerebral infarction Berberine C-reactive protein Complement component 3 Complement component 4
CLC: R743.3
Type: Master's thesis
Year: 2011
Downloads: 5
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Abstract

Objective:We measured the levels of serum C-reactive protein(CRP) and complement component 3(C3)、complement component 4(C4) in acute cerebral infarction of before berberine treated and after, to investigate the change and clinical significance of serum CRP and C3、C4 and to explore the cerebral protective effect of berberine and its probable mechanism of pathophysiology.Methods:We selected 66 patients with acute cerebral infarction as cerebral infarction group,the healthy check-up of 63 patients as control group,in accord with standard of gender and exclusion,age composition of comparable(P>0.05).Then we divided the patients with acute cerebral infarction into common group and berberine group according the different treatment,and in accord with standard of gender,age compositon and NIHSS scores of comparable (P>0.05).By the rate nephelometry method respectively in the groups,serum CRP and C3、C4,observe the change of serum CRP and C3、C4 levels within 48 hours of onset and the first 10 days after admission.For cerebral infarction patients neurologic deficits degree by the national institutes of health stroke scale(NIHSS) scores were evaluated in pathogenesis,within 48 hours of onset and the first 10 days to assess twice.All data using SPSS11.0 statistical software, test of significant level for bilateral inspection P<0.05.Results:1.The serum CRP level of cerebral infarction group within 48 hours of onset and the first 10 days after admission were significantly higher than those in control group(P<0.05),and the serum CRP level of the first 10 days after admission compared with it within 48 hours of onset have significantly increased (P<0.05).The serum C3 level of two times compared with the control have no significant difference.The serum C4 level of the first 10 days after admission was significantly higher than those in control group,but no significant difference compared with the level of 48 hours of onset.2.The serum CRP levels of two times with the first and the second times NIHSS scores have significant positive correlations(P<0.05), but the serum C3 levels have no significant correlations with two times NIHSS scores.The serum C4 level with the second times NIHSS scores have a significant positive correlation(P<0.05),with the first times NIHSS scores have no significant correlation.3.In cerebral infarction groups the level of serum CRP with C4 have significant positive correlations in two times,but have no significant correlation with the level of serum C3.4.The level of serum CRP of berberine groups within 48 hours of onset was no significant difference compared with the common groups,but the level of serum CRP of berberine groups the first 10 days after admission was significant lower than those of common groups(P<0.05). The level of serum C3、C4 have no difference with common group and berberine group in two times.Conclusions:1.The serum CRP level of cerebral infarction groups increased significantly (P<0.05),therefore the more serious of the neurologic deficits,the more raised of the level,indicate that CRP may participate in the process of the pathophysiology of cerebral infarction,and inflammation may play an important role in the injure of acute cerebral infarction..2.The serum C4 level of acute cerebral infarction patients significantly increased and the level also can reacte the severity of the illness,indicate that C4 may participate in the process of the pathophysiology of cerebral infarction.3.The serum CRP level of acute cerebral infarction patients have significantly positive correlation with the serum C4 level,indicate that the serum of CRP and the serum of C4 may have closely correlation in the process of the pathophysiology of cerebral infarction.4.Berberine can decreased the level of serum CRP,but have no influence on the level of C3、C4,indicate that berberine may relieve the inflammation of acute cerebral infarction,and may be beneficial for improving prognosis of acute cerebral infarction.

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