Dissertation > Excellent graduate degree dissertation topics show

Expression of Chemokine Receptor CCR5 in Human Non-small-cell Lung Cancer

Author: ZhouHao
Tutor: XuGang
School: Zunyi Medical College,
Course: Department of Cardiothoracic Surgery
Keywords: Non-small-cell lung cancer CC chemokine receptor 5 RANTES
CLC: R734.2
Type: Master's thesis
Year: 2011
Downloads: 4
Quote: 0
Read: Download Dissertation

Abstract


Objective:To detect the expression of chemokine receptor CCR5 in human Non-small-cell lung cancer and explore the role of CCR5 in lung cancer.Methods:Twenty samples of Non-small-cell lung cancer and Twenty samples of benign lung tumors were analyzed separately by immunohistochemical staining for CCR5 expression. MIP1α, MIP1βand RANTES concentrations in the serum of patients were measured by ELISA.Results:The expression of CCR5 was detected in Non-small-cell lung cancer (the positive rate was 65%), and in benign lung tumors(the positive rate was 15%,p< 0.05). RANTES concentration in the serum of Non-small-cell lung cancer patients increased(p< 0.01) while MIP1αand MIP1βchanged little compared with those in the serum of benign lung tumors.Conclusion:CCR5 is expressed in human Non-small-cell lung cancer, and it may play an important role in the pathogenesis of human Non-small-cell lung cancer. RANTES may be the main ligand of CCR5 in the progression of Non-small-cell lung cancer.

Related Dissertations

  1. Methylation of p16 Gene in Plasma and Tissues from Non-small Cell Lung Cancer Patients, Demethylation and the Biological Behavior of Lung Cancer Cell and Transcription of p16 Gene,R734.2
  2. Study on the Expression and Correlation of Metallothionein and Matrix Metalloproteinase-2 in Non-small Cell Lung Cancer,R734.2
  3. The Effect of RNA Interference-mediated ERCC1 Gene on the Chemo-treatment Sensitivity of NSCLC in Vitro,R734.2
  4. Non-small Cell Lung Cancer Analysis of 133 Cases of CVATS Lobectomy,R734.2
  5. Clinical Observation of Pemetrexed for Treating Advanced Non-small Cell Lung Cancer,R734.2
  6. Clinical Research on Detecing of the Combined Survivin mRNA with Cytokeratin 19(ck19) mRNA in Peripheral Blood of Non-small Cell Lung Cancer,R734.2
  7. The Molecular Biology of Rh-endostatin Plus Chemotherapy as Adjuvant Treatment for Non-small Lung Cancer,R734.2
  8. Effectiveness of Erlotinib as the Sennd-line Therapy in Patients with Advanced NSCLC,R734.2
  9. Enhancing Effect of Newcastle Disease Virus in Combination with Chemotherapy for Patients with Advanced Non-small Cell Lung Cancer,R734.2
  10. Clinical Study of Endostar Combined with Pemetrexed for Advanced Non-small Cell Lung Cancer,R734.2
  11. Association of Expression of ERCC1/RRM1 with Survival and Resistance to Platinum Inpatients with Ⅰ-ⅢA NSCLC,R734.2
  12. Analysis of Efficacy of Radiotherapy and 5-FU Slow Release Particles in Treating Non-small Cell Lung Cancer,R734.2
  13. Expression and Prognostic Significance of TS and BRCAl mRNA in Non-small Cell Lung Cancer,R734.2
  14. Restructuring Agkistrodon disintegrin Adinbitor human non-small cell lung cancer cell line A549,R285.5
  15. Non-small cell lung cancer with BMP-2 expression and significance of CD105,R734.2
  16. The Role of Integrin β1 Up-regulated in Resistance of Non-small Cell Lung Cancer to EGFR TKI,R734.2
  17. Study on Expression of Th17 Cells and Treg Cells in Non-small Cell Lung Cancer in Elderly and the Relationship with Immunosenescence,R734.2
  18. Preliminary Study on the Relationship between Non-small Cell Lung Epithelial Mesenchymal Transition and Metastasis and Its Influencing Factors,R734.2
  19. RT-PCR Detection Micrometastasis of Sentinel Lymph Node in Non-small Cell Lung Cancer and Its Clinical Significance,R734.2
  20. The Impact of mTOR Inhibitor RAD001 Combined Gefitinib on Human Non-small-cell Lung Cancer Cell Lines Which Are Egfr-wild and Resistant to Gefitinib,R734.2

CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
© 2012 www.DissertationTopic.Net  Mobile