Dissertation > Excellent graduate degree dissertation topics show

The Synthesis of Cyclodextrin-Modified Magnetic Nanoparticles

Author: CaoHaiNing
Tutor: HeJiang
School: Lanzhou University
Course: Analytical Chemistry
Keywords: Supramolecular chemistry Cyclodextrin Magnetic nanoparticles Silane coupling agent
CLC: TB383.1
Type: Master's thesis
Year: 2009
Downloads: 372
Quote: 0
Read: Download Dissertation

Abstract


Exterior of natural hydrophilic cyclodextrin molecule, and the inner cavity wall relatively hydrophobic, can be selectively and a large number of inorganic, organic and biological molecules, forming a stable master - guest complex (Host-guest inclusion complexes) or supramolecular aggregates, which is the most significant characteristics of cyclodextrins. Guest molecules (Guest molecule) spatial geometric properties (size and linear, etc.) is the inclusion of the match and the stability of polarity determinants. Which, by the seven glucopyranose ring consisting of β-cyclodextrin is most widely used, its hydrophobic cavity for accommodating the molecular selectivity for non-polar molecules solubilization, good compatibility with biological systems, as well as the bioavailability of the drug significantly improved, making the β-cyclodextrin in analytical chemistry, pharmaceutical and life sciences occupies a special importance. Magnetic nanoparticles are widely used in the life and biomedical fields. Crystal has a unique magnetic properties, that is, they force the outside of the remote sensing. As the external magnetic field is not retained after removed, superparamagnetic nanoparticles (especially Fe 3 O 4 nanoparticles) in vivo and in vitro biomedical applications get a number of studies. These applications include magnetic resonance imaging (Magnetic resonance imaging, MRI) to improve the contrast, target drug delivery, the magnetic separator is labeled cells and other biological applications. In summary, β-cyclodextrin as a multi-purpose supramolecular host compounds, causing researchers in related fields at home and abroad continued research interest, and has been in the food, pharmaceutical, cosmetics and other industries to achieve the scale and industrial applications; biocompatible magnetic nano-materials research is the current magnetic resonance imaging, drug molecules target transmission, cell separation and other biomedical fields of interest, in fact, magnetic nanoparticles have been practical in the clinical treatment Application. The paper consists of four chapters: Chapter One: Introduction. For cyclodextrin and its related research and applications, magnetic nano materials and related research progress and application of a general introduction. Chapter II: β-cyclodextrin modification. First, the use of imidazole and p-toluenesulfonyl chloride Synthesis of p-toluenesulfonyl imidazole, then the relative synthesis of green, in the water phase and the mild reaction conditions, using p-toluenesulfonyl been synthesized for the β-cyclodextrin imidazole modification, to obtain 6-TsO-β-cyclodextrin. Eventually 1 H NMR confirmed its formation. Chapter Three: iron oxide magnetic nanoparticles and magnetic particles prepared cyclodextrin modified. Firstly, co-precipitation method was Fe 3 O 4 magnetic nanoparticles, and then use a silane coupling agent 3 - aminopropyl triethoxysilane coated with 6 -TsO-β-cyclodextrin to obtain the target reaction of magnetic nanoparticles. Throughout the process, using XRD, FT-IR, TEM, TGA, and intermediates and products VSM monitoring generation and physical properties.

Related Dissertations

  1. Characterization and Properties of capsaicin / CD system,TQ450.1
  2. The Research of Supramolecular Complexes of Edaravone and Cyclodextrins,R943
  3. Molecular Recognition Based on β-cyclodextrin and Chemical Modified β-cyclodextrin as Receptor,O636.12
  4. Complex functions drug-loaded microspheres and in spinal cord injury treatment Application of,R943
  5. Cyclodextrin -modified magnetic nanoparticles synthesis and study drug carrier,TQ460.1
  6. Nano LaFeO 3 Controllable Synthesis and TiO 2 bridged construct composite photocatalyst,O643.36
  7. 3 - hydroxybutyrate , and 3 - ( 2,2,2 - trifluoro- acetoxy ) ethyl butyrate, and PMBCD chiral Theoretical Study,O621.25
  8. Studies on Magnetic Nanocomposite Particles as Drug Carriers for Photodynamic Therapy Agents,TB383.1
  9. Construction of Multi-responsive Gene Vector Via Layer-by-Layer Assembly,TB383.1
  10. Fabrications and Applications of Microelectrode Array of Silicon Dioxide Cavities and Magnetic Ferroferric Oxide Nano-Bioconjunctions,TB383.1
  11. The Effect of Membrane Rafts on Lateral Mobility of GABA_B Receptors,Q25
  12. Preparation and Characterization of PDCPD/Nano-SiO2 Composite,TB332
  13. Fabrication and Properties of YxGd2-xO3:Eu Powders and Nano-Sized Fe3O4/Y2O3:Eu Core-Shell Materials,TB383.1
  14. Synthesis of Polyaniline/nano-Manganese Dioxide Composite and Applications in Supercapacitors,TM53
  15. Studies on the Micro-, Nano-Materials Based on Polysaccharide Derivatives for Drug Carrier,TQ460.4
  16. Study on Preparation, Characterization and Properties of Inorganic Powder/Profiled Fibers/Polymer Composites,TB332
  17. The Study of Synthesis and Inclustion Behaviors of Several Cyclodextrin Derivatives with Drug Molecules,TQ460.1
  18. Effective active ingredient with skullcap Supramolecular Systems Role of,TQ461
  19. Effect of Cyclodextrins and Their Derivatives to Phenanthrene Biodegradation by White Rot Fungus,X172
  20. The Study and Application of Immunologic Nano-fluorescence Beads(INFB) on Hemopoietic Stem Cells’ Multiplication and Differentiation,Q813
  21. The Phase-transfer-catalysis Synthesis of Monodispersed Fluorescent Magnetic Nano-alloy-lanthanon Doped FePt:RE,O643.3

CLC: > Industrial Technology > General industrial technology > Materials science and engineering > Special structural materials
© 2012 www.DissertationTopic.Net  Mobile