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The Research on Mathematical Model of the Relationship between Intracranial Pressure and Cerebral Blood Flow

Author: XuLiWei
Tutor: QiuLiJun
School: Fourth Military Medical University
Course: Biomedical Engineering
Keywords: Intracranial pressure Cerebral blood flow Mathematical model Hemodynamic Cerebral blood flow autoregulation
CLC: R743
Type: Master's thesis
Year: 2009
Downloads: 115
Quote: 2
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Abstract


Cerebrovascular diseases, serious harm to human health, clinical research findings and cerebrovascular diseases and intracranial pressure (Intracranial Pressure, ICP) and other abnormal physiological parameters are closely related. Intracranial pressure fluctuations will affect the stability of cerebral blood flow, or even cause brain dysfunction. Autoregulation of cerebral blood flow (Autoregulation of Cerebral Blood Flow, ACBF) can guarantee intracranial pressure fluctuates between 5 ~ 13mmHg in the case of cerebral blood flow and metabolism remained at normal levels to match demand. In this paper, on the anatomy of the cerebral circulation and conclusions of previous models based on the analysis, the application of hemodynamic basic theory of intracranial pressure (ICP) and cerebral blood flow (Cerebral Blood Flow, CBF) A mathematical model for the simulation ; By studying cerebral blood flow autoregulation mechanism, obtained with intracranial arterial impedance relationships and take advantage of this relationship have made improvements to the model and the simulation calculation. This work mainly from the following three aspects: 1. Intracranial pressure and cerebral blood flow simulation on the relational model of cerebral blood flow and literature parameter model for analysis of cerebrospinal fluid circulation, the model includes the main impact of ICP biomechanical parameters, Kinetic parameters such as cerebrospinal fluid, intracranial cerebral hemodynamic parameters and resistance parameters. In the model to simulate the fluid circulating diode unidirectional, obtained by simulation waveform diagram of intracranial pressure, and the experimental data can be found in calculation results reflect clinical phenomenon. (2) Relationship between intracranial arterial impedance and research applications related hemodynamic principles, based on cerebral blood flow autoregulation mechanism, the establishment of a mathematical model reflecting the residual blood flow. Through simulation found that cerebral vascular occlusion occurs, the residual blood flow and residual flow channel mean radius, mean arterial pressure (Mean Arterial Blood Pressure, MABP), ICP, vascular stenosis length and other factors, including residual The average radius of the flow channel is a major factor. On mean arterial pressure and ICP, CBF and ICP, CBF and cerebral perfusion pressure (Cerebral Perfusion Pressure, CPP) were the experimental data were fitted by the fitting results derived arterial flow resistance (Resistance (arterial), Ra) and ICP relations function, use this function instead of intracranial pressure and cerebral blood flow between the mathematical model constants Ra, the model reflects the cerebral blood flow autoregulation. 3 intracranial pressure and cerebral blood flow relationships based on mathematical models to improve the ICP Ra functional relationship between, on the established relationship between intracranial pressure and cerebral blood flow mathematical model is improved using MATLAB equation of state of the model Solution. With elevated ICP 3mmHg, increased 1.5mmHg, reduce 3mmHg an example to illustrate the impact of considering the ACBF, CBF changes with the ICP, the effect is more ideal. Verify that the improved relationship between intracranial pressure and cerebral blood flow mathematical model can match some of the existing medical conclusions for clinical noninvasive monitoring of intracranial pressure provides a new idea.

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CLC: > Medicine, health > Neurology and psychiatry > Neurology > Cerebrovascular disease
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