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Capsule for civil experience side, Ugyen cuttlebone, Gallus gallus, Fritillaria, wide wood Coptis, antacid analgesic, convergence bleeding, the efficacy of the treatment of stomach and duodenal ulcers, chronic gastritis. The former taking the powder form of the poor drug compliance, taking large, not portable, storage, so we made it easy to take and carry the capsule formulation. In the preparation process of the study, we L9 (34) orthogonal test to optimize the Fritillaria, wide wood Coptis extraction process. In order to investigate berberine in Coptis extract indicators, plus water, boiling and boiling the number of visits, optimize the water extraction process conditions. The best conditions to establish water extraction process: boiling three times, each time plus 12 times the water boiling for 1 h. Quality standards by acid-base titration, thin-layer chromatography to develop the cuttlebone, berberine, wide wood identification methods. For cuttlebone in Ugyen capsule contents was added to dilute hydrochloric acid, to produce gas, and then identify the gas generated thereby infer whether cuttlebone. Berberine, Ugyen capsule after dissolved extract berberine standard spotting the same silica gel G plate, and expand into the developing agent, taken out to dry, the thin layer plate into UV lightbox under watch, you can see the corresponding position on the reference drug and reference substance was the same color spots. Wide wood of Ugyen capsule wide woody herbs were extracted and spotted the same silica gel G plate, expand into the developing agent, taken out to dry under the thin layer plate into UV light box watch, you can see the corresponding position on the reference drug and reference substance was the same color spots. In addition, we have developed a method for the determination of pharmaceutical ingredients CaCO3, total nitrogen content of Berberine as an indicator. Cuttlebone, by acid-base titration of the cuttlebone Ca2 ion quantitatively calculate sea cuttlebone in CaCO3 content. Gallus gallus, Kjeldahl nitrogen determination of the nitrogen content in the Gallus gallus measurement. Berberine, berberine content by HPLC determination. Proven test, acid-base titration, Kjeldahl method and HPLC method reproducibility, good stability, can be used as a the Ugyen capsule quality testing methods, and provides a the Ugyen capsule calcium carbonate content in the 45% to 55 % of the total nitrogen content of between 15 to 20%, the content of berberine 0.50 mg · g-1 ~ 0.60 mg · g-1 for qualified drugs. The Ugyen capsule each piece of 0.35 g, taken three times a day, every three. Pharmacodynamic study conducted by water stress, medication irrigation regimens mouse modeling experiments, Ugyen capsule treatment and prevention of acute gastritis and stress ulcer validated by experimental results, Ugyen capsule obvious effect of acute gastritis and stress ulcer treatment and prevention.
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