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To KMnO 4 < / sub> , the the NH 3 < / sub> and KMnO 4 < / sub> , the NH 3 < / sub> / DMSO · H 2 < / sub> O amination agent of 4 - amino - 3 ,5 - dinitro - , 2,6 - diamino - 3,5 - dinitro - pyridine, 2,6 - diamino - 3 ,5 - di nitropyridine nitrogen oxide and 4 - nitropyridine oxidative amination reaction . Focused on the amine reaction temperature , combined with the reaction mechanism of amine oxide material ratio, stirring way , solvents and ammonia concentration of reaction conditions on the yield of the target compound , to obtain the optimum process conditions . The amination reaction has raw materials cheaper, mild reaction conditions, simple operation , high yield . The more important is the oxidative amination reaction operation does not require special equipment to improve the safety of the reaction process , with a certain application prospect . Meanwhile , further study of 4 - amino-3 ,5 - dinitro- pyridine , 2,6 - diamino - 3 ,5 - dinitro- pyridine and its nitrogen oxides VNS amination reaction , and home and abroad Last VNS amination reaction results of 2,6 - diamino - 3 ,5 - dinitro- pyridine and its nitrogen oxides is improved, making 2,4,6 - amino-3 ,5 - dinitro - improve its yield of nitrogen oxides . In addition , also 4 - amino-3 ,5 - dinitropyridine , 2,6 - diamino - 3 ,5 - dinitro- pyridine and 2,6 - diamino - 3 ,5 - dinitro pyridine nitrogen oxide oxidation amination reaction results with the corresponding VNS amination reaction results for comparison , and further verification of the advantages of the oxidative amination reaction . And use of analytical tools such as MS, NMR analysis and identification of the molecular structure of the synthesized product .
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