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Pharmaceutical Study on Feiqiazhong Capsules

Author: YuanBin
Tutor: OuYangZhen
School: Jiangsu University
Course: Pharmacognosy
Keywords: preparation process quality standard herba Eupatorii icariin quercetin kaempferol
CLC: R286
Type: Master's thesis
Year: 2006
Downloads: 76
Quote: 0
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Abstract


A systematical study on the preparation techniques, quality standard, stability test of Feiqizhong capsules was carried out. The main contexts and conclusions were as following:1. To optimize the type and dosage of additive agents, the mono-factor design tests was used, and the factors of desiccation time, condition and grain’s moisture absorption were also examined, the preparation process was designed. The optimal conditions are as follow: the capsules were manufactured by wet granulation with 5% polypropylene acid ethanol solution was used to mix the micromeritics silicagel and drug powder in the partition of 10.7:1, and the outerside of capsules are polished and the quality is controllable. The results of middle scale experiment showed that the preparation is operationable reliablly and the quality of capsules is controllable.2. According to the relating references, the quality standards of herba Eupatorii was established. TLC was used to identify the main gradients of quercetin and kamepferol in herba Eupatorii:the silica gel thin layer plate and the developing agent consisting of a mixture of toluene-ethyl acetate-ethyl acid（9:3:1） were used, and the allunim trichloricide-ethanol solution was used to react to the gredients stains.The relative flow value of quercetin is 0.54, and the value of kaempferol is 0.62. HPLC was used to determinate the contents of quercetin and kamepferol, and the method was validated. A C18 column and the mobile phase consisting of a mixture of methanol-0.4%H3PO4（60:40）are used to determinate the contents with the wavelength of 370nm and the flow rate of 0.6ml/min at 30℃. The method is sensitive, reproducible and accurate.3. The quality standard of Feiqizhong capsules was established. TLC was used to identify the herba Epimedii, oleum Viticis negundo, radix Salviae miltiorrhizae, fructus Psoraleae, radix Astragali, and HPLC also was used to analysize the content of icariin and clenbruterol hydrochloride. The method are validated. A C18 column and the mobile phase consisting of a mixture of methanol-0.4%H3PO4（55:45）are used to determinate the content of icarrin with the wavelength of 270nm and the flow rate of1.0ml/minat35℃. 4. The stability of Feiqizhong capsules was studied for 3 months. The results indicated that the factors of characteristics, identificationtest, content determination and hygienics check remained unchanged. It showed that the quality of Feiqizhong capsules was stable.

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CLC: > Medicine, health > Chinese Medicine > Of Pharmacy > In drugs
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