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Completion of the thesis flavored flavored loquat Qingfei capsule drug group (skullcap, gardenia, hawthorn, gypsum) pharmaceutical research. Acne common chronic pilosebaceous inflammatory skin disease, a high incidence of. Due to the complex causes of acne, western medicine there are limitations and side effects of traditional Chinese medicine in China is a long history of acne treatment, but the clinical formulation, there is no formation of Chinese medicine products for treating acne. The loquat Qingfeiyin Yi Zong Jin Jian reproduces the treatment of pulmonary wind acne the classic prescription, clinical application loquat decoction in the treatment of acne vulgaris efficacy exact, but has not yet developed into a mature technology, easy to use traditional Chinese medicine preparation. The author of the research team, by the side of the loquat Qingfeiyin the basis of modern clinical experience appropriate flavored developed into a flavored loquat Qingfei capsule for the treatment of acne vulgaris. In this paper, the main research contents flavored medicine group Pharmaceutical Research. The paper also carried the the fenugreek aroma components analysis research. Fenugreek is native to the western coast of the Mediterranean, has always been used as a spice and crude drugs. Fenugreek oil with a pleasant caramel-like roasted, slightly sweet and has a bitter taste, has been widely used in tobacco, food. The no characteristic flavor components of fenugreek seeds in reports. The main content and conclusions of this study are as follows: 1. According to the physical and chemical properties of the active ingredients contained in each herb flavored medicine group, to take the technical route of the packet to extract the active ingredients: the skullcap single mention; gardenia, hawthorn SHININGHUB; gypsum is used as medicine in the form of pharmaceutical excipients. 2. Baicalin yield process indicators, studies skullcap extraction and purification: the herbs add boiling water extraction, plus 10 times the amount of the first, second 8 times the amount each time 1.0h The filtrate was extracted static set, centrifuged, the supernatant was adjusted pH 1.5,60 ° C incubated 30min, allowed to stand, centrifugation, sedimentation plus 10 times the amount of water, stir, adjusting the pH to 7.0, add an equal amount of ethanol, centrifuged, the supernatant was adjusted with concentrated hydrochloric acid pH of 1.0,60 ° C for 30 minutes and let stand, centrifuged, and the pellet was washed with water until neutral, 60 ° C dry skullcap extract. Skullcap extract material was 0.14 g / g crude drug, baicalin was 119.57mg / g. Scutellaria root extract the baicalin content of the material 86.6%. 3. To Geniposide, total flavonoids yield process indicators, studies gardenia, the hawthorn extract process for herbs plus 10 times the amount of 60% ethanol was extracted three times, each time 1.5h. Crude extracts by macroporous resin purification resin screening, dynamic adsorption and orthogonal experiment to determine the best purification process for each 5.0 g (wet weight) AB-8 resin treatment gardenia, hawthorn sample solution 60ml (0.05 g crude drug / mL, pH 3-4), flow rate 0.5mL/min, adsorption resin was eluted with 40 ml of 50% ethanol, 60 ° C dry gardenia, hawthorn extract. Gardenia, hawthorn extract material was 0.08 g / g crude drug, the geniposide a rate of 21.8 mg of / g, total flavonoids was 22.5 mg of / g; gardenia, the hawthorn extract Geniposide content of 27.3% , total flavonoids content of 28.1%. 4. Gardenia, hawthorn extract Gardenia using thin-layer chromatography for the qualitative identification of the intermediate Geniposide content using high performance liquid chromatography, gardenia, hawthorn extract quality standards. Using HPLC herbs skullcap, Scutellaria extract fingerprint studies, the results show that the herbs, extracts, there is a good correlation between HPLC fingerprint. 5. Flavored Medicines intermediates preliminary pharmacodynamic studies, mouse ear swelling test showed that flavored medicine group the intermediates has good anti-inflammatory role; Modified medicine group can cause significant reduction of the gland spot area of ??the golden hamster, indicating that The flavored drug group that may affect the level of androgen in the sebaceous glands. 6. Experiment showed that supercritical CO 2 the oil extraction fenugreek conditions: the leaching 3h and the dynamic extraction 6h, extraction temperature 40 ° C, extraction pressure 25Mpa, separation temperature 60 ° C, atmospheric pressure separation, mixing into 80% ethanol as a modifier, supercritical the CO 2 extracted fenugreek oil was 89.5mg / g fenugreek bar seed. 7. Extract from fenugreek oil, esterified by GC-MS analysis showed that contains a lot of fatty acids. 8,11 - octadecadienoic acid, the 18 carbon -9 - acid, palmitic acid is the main peaks substances. Not detected characteristic flavor components of fenugreek seeds. 8. Fenugreek seeds characteristic flavor components of fenugreek lactone in the literature on the basis of quantitative analysis methods, the use of solvent extraction and Oldershow column concentrated fenugreek seeds, fenugreek lactone, gas chromatography - mass spectrometry identified fenugreek lactone structure, gas chromatography external standard method for quantitative analysis report for the first time in the country fenugreek seeds, fenugreek lactone content of about 4.5mg/kg fenugreek lactone content.
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