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Study on the Effects of Fish Oil on Intestinal Mucosal Immune in Rats

Author: HeXianJing
Tutor: WuRui
School: Heilongjiang Bayi Agricultural University
Course: Basic Veterinary Science
Keywords: Fish oil Intestinal flora Intestinal Morphology Mucosal immunity SD rats SIgA
CLC: S852.4
Type: Master's thesis
Year: 2009
Downloads: 125
Quote: 3
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Abstract


In order to study the impact of fish oil on rat intestinal mucosal immune function . SD rats , the test done in animal models , the application of gradient dilution culture method for the determination of changes in the intestinal flora of weaned SD rats to explore the impact of fish oil weaned SD rat intestinal biological barrier ; HE staining method for the determination of weaned SD rats changes in intestinal morphology of fish oil on weaning SD rat intestinal mechanical barrier ; by artificial replication colitis model , using immunohistochemistry method to explore the fish oil inflammation damage in rats colitis and intestinal SIgA secretion and rats. The test results showed that the diet supplemented with 0.5% fish oil can improve average daily gain of weaned SD rats , reduce material weight ratio , thus affecting the production performance of weaned SD rats ; fish oil can improve weaned SD rats Immune Organ Index to reduce intestinal Enterobacteriaceae and Staphylococcus content , reduce bacterial translocation ; fish oil can improve weaning in SD rats bowel mucosal thickness , muscle thickness , villus length and villus width ; fish oil can reduce colitis the mouse disease activity index , colonic mucosal injury and colon tissue damage , increased serum and colonic tissue IgA, IgG, IgM content , improve colon SIgA expression. To sum up, the fish oil by improving intestinal biological barrier and mechanical barrier and immune barrier by rat intestinal mucosal immunity .

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CLC: > Agricultural Sciences > Livestock, animal medicine,hunting,silkworm,bee > Animal Medicine ( Veterinary Medicine) > Basic Veterinary Science > Animal Immunology
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