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Objective: To investigate the acute brain injury induced systemic inflammatory response syndrome (systemic inflammatory response syndrome, SIRS) and the incidence of multiple organ dysfunction syndrome (multiple organ dysfunction syndrome, MODS), caused by the detection of acute brain injury SIRS, acute brain injury caused MODS neutrophils, platelets, and tumor necrosis factor-α (TNF-α), interleukin-prime -6 (IL-6), C-reactive protein (CRP) change with the simple acute cranial brain injury group and normal control group for comparison, to reveal neutrophils, platelets, tumor necrosis factor-alpha, leukocyte interleukin -6, C-reactive protein in acute brain injury induced SIRS and MODS conversion mechanism diagnostic value and pathophysiological significance for early clinical diagnosis and prevention and treatment of acute brain injury induced SIRS and MODS provide a theoretical basis and laboratory parameters. Methods: Case Source neurosurgery of our hospital from June 2008 to November 2009 admitted to trauma 2 days for treatment of acute brain injury in 96 patients, age 42.16 ± 3.61 years, were divided into three groups: (1) simple acute 42 cases of traumatic brain injury group; (2) acute brain injury caused by systemic inflammatory response syndrome (SIRS group) 34 cases; (3) acute brain injury caused by multiple organ dysfunction syndrome group (MODS group, 20 cases); Also select the same period in our hospital 30 cases of healthy people (age 42.32 ± 4.76 years) served as normal controls. In all cases except for the recent (within 14 days) the vital organs of the infection, with obvious heart lung and kidney disorders, cancer, immune system diseases, surgery, trauma and heart stroke six months. All cases of trauma hospitalized for 2 days and the normal control group in the early morning fasting venous blood 6ml put in ordinary test tubes 3, do a blood test neutrophil and platelet; 2 indwelling one hour at room temperature, 3000r / min for 10min, take the upper serum to take double antibody sandwich (ELISA) assay TNF-a and IL-6; indwelling one hour at room temperature 3, 3000r/min centrifugal 10min extracted upper Serum, serum was separated by immune The cloud Quantitative determination of serum C-reactive protein. Application SPSS15.0 statistical software for statistical analysis of the experimental data are expressed as mean ± standard deviation (X ± s), groups were compared using the t-test, P lt; 0.05 for the difference was significant. The results: 1. Research group with acute brain injury resulted in SIRS occurrence rate of 35.42%, acute brain injury lead to the occurrence of MODS was 20.83%, 58.82% induced MODS incidence of acute brain injury caused by SIRS. The MODS caused acute brain injury have occurred in advance SIRS. The team purely acute brain injury group, acute brain injury induced SIRS group and the acute brain injury caused by the MODS patients neutrophils, platelets, tumor necrosis factor-α, leukocyte interleukin -6, C-reaction The protein content was significantly higher than the normal control group (P lt; 0.01); and acute brain injury caused by SIRS group was significantly higher than the simple acute brain injury group (P lt; 0.01); acute brain injury caused by MODS was significantly high acute brain injury induced SIRS (P lt; 0.01), the overall presentation of the dynamic gradually rising trend. 3 The research group with acute brain injury MODS caused the integral group (score ≥ 9 the grouping and integral lt; grouping) neutrophils, platelets, tumor necrosis factor-α, leukocyte interleukin -6, C-reactive protein levels SIRS group (P lt; 0.01) were significantly higher than those caused by acute brain injury; induced MODS in patients with acute brain injury, serious (score ≥ 9 points) neutrophils, platelets, and tumor necrosis factor-α, interleukin Su -6, C-reactive protein was significantly higher than the mild (integral lt; 9 points) (P lt; 0.01). 4 The discussion group with acute brain injury caused by neutrophil patients with MODS death group, platelets, tumor necrosis factor-α, leukocyte interleukin -6, C-reactive protein was significantly higher than the survival group (P lt; 0.01). Neutrophils, platelets, tumor necrosis factor-α, leukocyte interleukin -6, C-reactive protein biochemical markers with acute brain injury caused SIRS and MODS relevance of turn: neutrophils gt ; C-reactive protein the gt; tumor necrosis factor-α gt; interleukin -6 gt; platelets. Conclusion: Patients with acute brain injury can induce a systemic inflammatory response syndrome (SIRS) and acute brain injury caused by multiple organ dysfunction syndrome (MODS) incidence foundation. 2.SIRS the MODS caused acute brain injury pathogenesis, dynamic monitoring of acute brain injury patients with neutrophils, platelets, and tumor necrosis factor-α, leukocyte interleukin -6, C-reactive protein changes in acute cranial brain damage lead to the occurrence of SIRS and MODS high warning value, provides a theoretical basis for the early diagnosis and prevention of the occurrence of SIRS and MODS and judgments of acute brain injury prognosis and laboratory parameters. 3 patients with acute brain injury granulocytes, platelets, and tumor necrosis factor-α, leukocyte interleukin -6, C-reactive protein levels as a judge acute brain injury caused by SIRS, acute brain injury caused by MODS severity and prognosis and outcome indicators, and timely guidance early clinical treatment is of great significance to the the MODS transition early diagnosis of SIRS very important reference value. Dynamic monitoring of the disease process in patients with acute brain injury, play a role in early warning and SIRS to MODS transition early diagnosis is very important reference value indicators are: neutrophils, C-reactive protein and tumor necrosis factor-α, interleukin-6 and platelets can play a diagnostic marker.
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