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Background and Purpose: In recent years osteopontin (OPN) and tumor relationship more, and it is linked to the integrin and VEGF but little studied in this experiment by the research OPN to integrate the prime v 3 and VEGF in epithelial the expression level of ovarian cancer, initially explore OPN, v 3 and VEGF in epithelial ovarian cancer occurs role in the development, invasion and metastasis, possible mechanisms to seek possible tumor markers of ovarian cancer. Methods: Immunohistochemical detection of 50 cases of epithelial ovarian cancer surgery standard wood OPN, v 3 and VEGF, analysis of their relationship with clinicopathological parameters and their mutual relations. Results: OPN, v 3 and VEGF immunohistochemical expression was mainly localized in the cytoplasm of cancer cells, the cell cytoplasm yellow or brown positive cells. The statistical analysis, OPN, v 3 and VEGF expression of the ovarian cancer group were higher than the normal group, the benign group, the difference was significant (p lt; 0.01). The OPN, αvβ3 and VEGF positive expression rate in 50 cases of ovarian cancer were 74.0%, 64.0% and 72.0%. Increased with clinical stage of OPN, v 3, and VEGF positive expression rate increased expression of OPN in advanced ovarian cancer, v 3 and VEGF were higher than early ovarian cancer, a statistically significant difference (P lt; 0.01 ); poorly differentiated ovarian cancer OPN and alpha V beta 3 expression level was significantly higher than well-differentiated ovarian cancer (P lt; 0.01), the expression of VEGF and histological grade was no significant difference (P GT; 0.05); different histological type OPN, αvβ3 and VEGF expression level was not statistically significant (P gt; 0.05); lymph node metastasis in ovarian cancer OPN, v 3 and VEGF expression than that without lymph node metastasis of ovarian cancer, the differences were statistically significant ( P lt; 0.01). OPN and αvβ3, VEGF expression in ovarian cancer was positively correlated. v 3 and VEGF expression in ovarian cancer. OPN, v 3, and VEGF expression was significantly associated with lymph node metastasis of ovarian cancer. Conclusions: 1 in epithelial ovarian cancer tissues, OPN, v 3 and VEGF showed expression status. OPN and alpha V beta 3 expression and clinical stage, histological grade, lymph node metastasis-related; expression of VEGF with clinical stage, lymph node metastasis correlation. Suggesting that they may play an important role in the occurrence and development of ovarian cancer invasion and metastasis. 2, OPN and alpha V beta 3 expression consistent OPN increased expression of the alpha V beta 3 upregulation. OPN and VEGF expression was significantly associated, OPN may be involved in the process of ovarian cancer angiogenesis. In ovarian cancer, OPN and v 3, VEGF protein expression was positively correlated prompt OPN and v 3, VEGF may synergistically promote the development of ovarian cancer. 5, OPN, αvβ3 and VEGF expression was significantly associated with ovarian cancer lymph node metastasis, suggesting that the combined detection of three indicators predict tumor metastatic potential and estimate the prognosis of patients with a positive role in guiding the clinical assessment of ovarian cancer progression, OPN may be ovarian early event in the carcinogenesis process, can be used as a biological marker for monitoring ovarian cancer malignant progression.
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