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Objective: To investigate patients with bronchial asthma serum tumor necrosis factor-α (TNF-α) and ultra-sensitivity C-reactive protein (hs-CRP) levels and FEV1% pre (forced expiratory volume in one second percentage of predicted value), serum total IgE, peripheral blood eosinophil count (PBEC) relationship. METHODS: From March 2007 to May 2008 collected with acute exacerbation of bronchial asthma in 34 patients; normal control group of 20 patients, testing patients with asthma and normal control group before and after treatment serum TNF-α, hs-CRP, serum total IgE, peripheral blood eosinophils and lung function. ). statistically significant (P lt; 0.05), but the mild to moderate group and severe group, the difference was not statistically significant (P gt; 0.05); (3) peripheral blood eosinophil count before treatment levels [(0.47 ± values ??were 6.641,7.136, P lt; 0.05). After treatment, peripheral blood eosinophil levels and normal control group, the difference was not statistically significant (t value of 1.322, P gt; 0.05). the normal control group, the difference was statistically significant (P lt; 0.05), but the mild to moderate group and severe group difference was not statistically significant (P gt; 0.05); (4) patients with bronchial asthma exacerbation pretreatment serum TNF- α levels and total IgE levels were positively correlated with lung function FEV?% and FEV? / FVC was negatively correlated (r = 0.799, - 0.693, -0.674, P lt; 0.05), and peripheral blood eosinophil count was not found significant correlation; (5) serum hs-CRP levels before treatment [(1.62 ± 1.14) mg / L] was significantly higher than after treatment [(0.50 ± 0.45) mg / L] and normal control group [(0.49 ± 0.17) mg Group of patients with severe asthma, serum hs-CRP levels [(3.33 ± 1.74) mg / L] was significantly higher than the mild to moderate group [(0.58 ± 0.35) mg / L] and normal control group [(0.49 ± 0.17) mg / L] The difference was statistically significant (t values ??were 4.467,10.266, P lt; 0.05), mild to moderate levels of hs-CRP group [(0.58 ± 0.35) mg / L] was also significantly higher [(0.49 ± 0.17 = 0.656, P lt; 0.05), and other clinical indicators such as eosinophils, pulmonary function did not find a significant correlation (P gt; 0.05). Conclusions: 1, serum TNF-α can reflect the degree of inflammation of asthma, combined TIgE, eosinophil count and more objective assessment of lung function in asthma, is expected to provide a new clinical diagnosis and treatment ideas. 2, serum hs-CRP as inflammatory markers reflect the degree of inflammation of asthma, asthma prevention and treatment of certain clinical predictive value.
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