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Compared Three-dimensional Radiotherapy with Conventional Radiotherapy on the Curative Effection and Dose Distribution of Gliomas

Author: ZhouLue
Tutor: ShenLiangFang
School: Central South University
Course: Oncology
Keywords: Glioma three-dimensional conformal radiotherapy conventional radiotherapy 3-year survival intracranial high-pressure
CLC: R739.41
Type: Master's thesis
Year: 2011
Downloads: 41
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Abstract

Background and Objective:Glioma is the most common intracranial neoplasm, which is about 35--60% percent of the total brain tumors, surgical resection is the main treatment, but because the the biological characteristics of tumor, and to protect important functions,it often difficult to achieve complete resection, which cause its recurrence rates high. Radiation therapy can eliminate residual lesions, reduce the recurrence, and prolonging the survival time, thus became the important auxiliary treatment of postoperative glioma. This experiment is aim to compared with Three-dimensional conformal radiotherapy for and conventional on the curative effect of gliomas and dose distributionMethods:Reviewing and summarizing the patients diagnosed with gliomas 109 cases in XiangYa hospital from 2005.4 to 2009.4.all patients had complete medical records and complete follow-up data. Including conventional radiotherapy 55 cases, three-dimensional conformal radiotherapy 54 cases; The WHO pathologic stage:Ⅰ+Ⅱgrade49 cases,Ⅲ+Ⅳ60 cases; Male76 cases, female 33 cases; Age(?)40years60 cases, age<40years 49 cases;median ageis 38 years (range 5-72). In the three-dimensional conformal radiotherapy group plan, making the corresponding simulation design plan for conventional radiotherapy,and compared the diffirent distributionResults:using the phone and mail pays a return visit, return rate is 98%. Median follow-up time is 30 months (8-69 months). three-dimensional conformal radiotherapy patients with 1,2,3 years of survival 70.9%,, 58.5%,91.2% respectively, conventional radiotherapy patients with 1,2,3 years of survival 87.2%,57.1% 61.5%, respectively, and there were no statistically significant,; Both radiation process for the incidence of intracerebral high-pressure respectively 8/55 and 12/54 (P=0.332); The incidence of relevant sequela after radiotherapy is 5/55 and 11/54. respectively.conformal index (CI) of Three-dimensional conformal radiotherapy and ordinary radiation shows:the CI of the PTV1 IS 0.997 and 0.995 respectively, was not statistically significant; the CI of PTV2 is 0.809 and 0.81 respectively and not statistically significant. Both the dose not treatment of wild homogeneity (IC) comparison shows:the IC of PTV2 is 0.297 and 3.233 respectively and it has statistically significant; The IC of PTV1 is0.108 adn 0.484 respectively. Both the average dose of PTV2 is 59.1±2.30 Gy,56.3±5.3 Gy respectively; and The average dose of PTV1 is 61.4±3.1 Gy 60.6±6.2 Gy; and The average highest doses of PTV1 is 73.4±3.1Gy and 62.9±7.2 Gy respectively The average highest dose of PTV2 is 63±3.2 Gy and 73.4±7.2 Gy respectively. the average dose of brainstem are 14.7±4.6 Gy and 16.1±6.2 Gyconclusion:(1) the 3-year survival of three-dimensional conformal radiotherapy and conventional radiatiotherapy for glioma has no obvious difference.(2) the three-dimensional conformal radiotherapy lleiate the immediate and long-term adverse reaction compared with conventional radiotherapy.(3) the dose distribution of 3-dimensional conformal radiotherapy is better than that of the conventional radiotherapy.

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