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Objective: To explore the clinical value of dynamic monitoring in the respiratory mechanics of neonatal respiratory distress syndrome during mechanical ventilation.Methods: According to prognosis,55 newborns with NRDS who had been treated with pulmonary surfactant in our hospital NICU from Jan.2006 to Dec.2008 were divided into 2 groups.There were 44 newborns in survival group and 11 newborns in death group.The dynamical changes of Crs、RI、OI、PA-a02 and Pa02 were measured during mechanical ventilation.Results:1.At 6h after mechanic ventilation, there were significant differences in Crs,PA-aO2,OIand RI between the survival group and the death group(t= 6.871,-6.450,-10.316,-8.815 P<0.05).2.At 6h after mechanic ventilation, there was no significant differences in PaO2 between the survival group and the death group(t= 1.763 P>0.05 ).3. In the survival group,RI, PA-a02 and OI decreased with the time of ventilation , and there were significant differences among the different time point(F=215.56,147.85,384.64 P<0.05).4. In the survival group,Crs increased with the time of ventilation,and there were significant differences among the different time point(F=292 P<0.05).5. In the death group,RI, PA-a02 and OI increased respectively just before dying than at 6 h after mechanic ventilation(t=-5.699,-5.578,-6.924 P<0.05).6. In the death group,Crs decreased respectively just before dying than at 6 h after mechanic ventilation(t=11.767 P<0.05).7. Crs was negative correlated with OI、RI、PA-aO2 (r=-0.813, -0.8,-0.859,P<0.05).Conclusion: motioring in NRDS children’s dynamic changes of Crs, RI, OI, PA-aO2 can help observing effect of treatment , guiding ventilator treatment, grasping the opportunity and assessing the prognosis offline in NRDS.
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