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Star Po anti- epileptic tablets antiepileptic effect and its mechanism of

Author: ShengLiangLiang
Tutor: JiaDong
School: Liaoning University of Traditional Chinese Medicine
Course: Pharmacology
Keywords: XingPuKangXian Tablets Epilepsy Convulsion Pilocarpine
CLC: R285.5
Type: Master's thesis
Year: 2011
Downloads: 11
Quote: 0
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Abstract


Objective:To investigate whether XingPuKangXian Tablet have the function of sedaion and antiepileptic ,and research the mechanism of its function.Methods:To measure the maximum tolerated dose on mice of XingPuKangXian Tablets. Through experiments of XingPuKangXian Tablets on mice by low limen quantity pentobarbital sodium in hypnosis;prolong the sleep duration on mice by limen quantity pentobarbital sodium;effect on mice of strychnine,thiosemicarbazide, pentylenetetrazol model.To observe the content of Glu、Asp、GABA、5-HT、NO、Na+ -K+-ATPase in pilocarpine model rat brain,NO、IL-1βin pilocarpine model rat serum;and observe general pathology,the expression of NMDAR1、GABARAα1、Bax、Bcl-2 in pilocarpine model rat brain tissue.Results:Acute toxicity text showed that maximum tolerated dose of mice to DianXianQing Tablets is 625.0g/kg/day. It is 441 times as the dose in people （adult weight by 70kg）. XingPuKangXian Tablets can add the number of sleep mice inlow limen quantity pentobarbital sodium in hypnosis, prolong the sleep duration on mice by limen quantity pentobarbital sodium. XingPuKangXian Tablets can partly against the convulsion caused by strychnine,thiosemicarbazide, pentylenetetrazol. XingPuKangXian Tablets can decrease the content of NO、IL-1βin pilocarpine model rat serum,decrease the content of Glu、Asp、NO in pilocarpine model rat brain, increase the content of GABA、5-HT、Na+ -K+-ATPase,It can increase the expression of GABA RAα1、Bax、Bcl-2,and decrease the expression of NMDAR1.Conclusion:XingPuKangXian Tablets have the function of sedaion and antiepileptic

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