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Objective To study the granisetron hydrochloride vasovagal syncope (VVS) intervention role . 24 New Zealand white rabbits were randomly divided into blank control group (control group) and granisetron intervention group ( granisetron group) , n = 12 . The control group received normal saline intravenously ; the granisetron group using intravenous granisetron intervention . Establishment of rabbit vascular fans go sexual syncope model , each in the bloodletting process to take four time points for T1 , T2, T3 , T4 , comparison group at each time point bloodletting time , blood 5 - HT amine (5-HT) the quality concentration and the total discharge of blood, and heart rate monitoring throughout the experiment , changes in blood pressure . 1 granisetron can extend reflecting increased blood pressure in the process of rabbits were bled and decompensated reduced time , make the extend the total Bloodletter time period (Group T2 , T3 , T4 pairwise comparison , P LT ; 0.01 ) . 2 groups There were no significant differences in mean blood pressure and heart rate in T2 . The mass concentration of 5-HT 3. Bloodletting process tends upward trend, significantly elevated in the blood pressure decreased significantly (control group T3 and T1 , P LT ; 0.0001, T4 and T3 comparison , P LT ; 0.001) . Granisetron group than in the control group to the T4 when put blood increased significantly [ ( 76.10 ± 15.36 ) mL vs ( 55.30 ± 13.52 ) mL , P lt ; 0.05 5 10 rabbits in the control group at the end of the experiment convulsions , and ultimately blood pressure , heart rate , disappearance of death (83% ) . Granisetron group of 11 rabbits no obvious convulsions (92%) died due to respiratory arrest . Conclusion granisetron hydrochloride can significantly weaken or to avoid the emergence of the Bezold-Jarisch reflex , enhanced the rabbit hemorrhagic model of cerebral ischemia and acute body insufficiency tolerated , so as to achieve the purpose of the prevention and treatment of VVS .
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