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Background Cardiovascular disease is a serious harm to human health and the life of the common diseases and frequently-occurring disease, coronary atherosclerosis (atherosclerosis, AS) and thrombosis lead to coronary heart disease pathological basis. China has experienced studies suggest that the local and systemic inflammatory in the the plays a important the role of in in the in the the generate of the of the the occurrence of of the atherosclerosis, The the development of and an complications of the, a more and more body of the evidence display in the the in the the the of the the occurrence of the development of the process of coronary atherosclerosis, the inflammation plays an in recent years a key role. Inflammation is the the atherosclerosis vulnerable plaque rupture the the link in of the the the the beginning of moving of the evoked acute coronary syndrome event, the the the mRNA and protein of expression of of of the inflammatory factor was significantly in the the in the plaque increase the, the the the balance disorders of of the the inflammatory and anti-inflammatory of factor is to plaque rupture important molecular biological mechanisms, and therefore the level of inflammatory factors as the evaluation of the stability of the plaque, and also as the risk factors and predictors of future cardiovascular events. Of Traditional Chinese Medicine has the multi-pathways, multi-link, multi-target the treatment of disease and the the non-performing reaction is light, and, etc. characteristics of, and can be through the protection of the vascular endothelial cells, to adjust the lipid metabolic, inhibition of inflammation reaction and inhibition of that the more than one angle of the collagen fiber degradation of, and, etc. stable athero-hardening plaques block, in the treatment of coronary heart disease aspects of to play a out of the the potential of the curative effect advantage. In recent years, a variety of Chinese medicine have already been used to to the prevention and treatment of sclerosis of of arterial porridge kind its related diseases, and shows good the role of for, but formed throughout As Yu the artery atherosclerotic plaque, the The whether the the of the inflammatory response in the the rupture process is be similar to the TCM of the the? Gan Wen, with the the two types of effects of the medicine at odds drug of the the bitter cold of inhibition of the artery porridge the kind hardening inflammation whether effective as well as the the contrast to of the two types of drug efficacy, the current home and abroad there is no Related is reported.. Is there no heat-toxin Objective To observe the sweet warm and bitter cold medicine for coronary atherosclerotic heart disease in patients with inflammatory reaction, of different ages, different duration of clinical efficacy in patients with coronary heart disease, compared to the relative efficacy of the two drugs, explore the sweet warm bitter cold of the drug inhibition of the the the possible mechanism of of the the coronary heart disease inflammation reaction, of proven the relationship between the atherosclerosis inflammatory reaction and TCM heat-toxin of the. Method 1. The the object of study select that the 117 cases of a clear diagnosis in patients with coronary heart disease were randomly divided into three groups of: control group, Astragalus the group and rhubarb of group, control group was given conventional the treatment of (Betaloc the 25mg, Daily 2 times a and worship aspirin 100mg, day 1), Astragalus group and rhubarb group added in the conventional treatment based on the Chinese herb astragalus and rhubarb. And Astragalus group and rhubarb group, patients were divided into two groups according to age: young and middle-aged and elderly groups; according to the course of the disease is also divided into two groups: the long duration of the group and the short duration of group. All patients treated for three months after the follow-up, follow-up period is not taking the same or inflammation of coronary heart disease that affect drug. 2. History taking and physical examination subjects are detailed records of age, gender, disease duration, history of smoking and drinking history, past medical history, cardiovascular and cerebrovascular disease, family history of vascular risk factors, measurement recorded height, weight and calculate body mass index (BMI), to record heart rate (RHR), blood pressure (BP), and system checks. Biochemical tests selected candidates within 24 hours and after 12 weeks of treatment after admission Determination of liver function, kidney function, fasting blood sugar (FBS), serum total cholesterol (total cholesterol, TC), triglycerides (triglyceride, TG), high density lipoprotein cholesterol (high-density lipoprotein cholesterol, HDL-C), low-density lipoprotein cholesterol (low-density lipoprotein cholesterol, LDL-C) and the the the level of of lipoprotein a (LPa). Detection of serum inflammatory factors were taken before and after treatment in patients with fasting blood immune scattering turbidimetry of serum high sensitivity C-reactive protein (high-sensitivity C-reactive protein, hs-CRP) level, and at the same time using the enzyme-linked immunosorbent adsorption Law (enzyme-linked immunosorbent assay, ELISA) detection the serum white interleukin -6 (Interleukin-6, IL-6), tumor necrosis factor α (tumor necrosis factor-alpha, TNF-α), TOLL-like receptor 4 (Toll- the level of of the like receptor 4, TLR4). 5. Detection of endothelial function were taken before and after treatment in patients with fasting blood, with nitrate enzyme reductase assay of plasma nitric oxide (Nitric oxide, NO) level was measured by radioimmunoassay of plasma endothelin-1 (Endothelin-1, ET -1) the level of. 6. Statistically analysis of statistical software of the Application of SPSS carried out the statistically processing (version 13.0; SPSS Inc), data in order to the average number of ± the standard deviation of ((?) ± SD) said that the, the measurement data are conducted the t-test, count data adopts chi-square test , are the number of to was used to compare the single factor analysis of variance, in order to P <0.05 as the was there are statistically significant difference in in the the multi-group inter-of the. Results five cases of in patients with failed to the completion of All experimental, has a the the in patients with of the complete blood follow-up data of the a total of 112 cases of, of which control group 30 cases, 40 cases of of the the 42 cases of the Astragalus group and rhubarb group. The three groups of patients in the the the former Age of the treatment of, gender, course of the disease,-smoking the history of, body weight index, blood biochemical indicators, heart rate, blood pressure as well as past medical history and and, etc. blood vessels dangerous factors was no significant the sexual differences in. According to the the the Age and the course of the disease of the different will be the traditional Chinese medicine group patients were divided into to the the young and middle-aged group Astragalus group / rhubarb group, the the astragali group of the the elderly group / rhubarb group and the short course of the disease group Astragalus group / rhubarb group, the long-course of the disease group Astragalus Group / rhubarb group. (1) before and after medication in each group of the general situation comparison. After the the the treatment of, the control group outside the the change the of In addition to the BP and the RHR of the, the rest of before the the the indicators with the treatment of of of compare was no difference in statistically significance. The Astragalus the group and rhubarb of group RHR, there are obvious decline in (P <0.05 and P <0.01) in the the of SBP, the DBP has compared with before treatment. After the the the treatment of of with the control group compare that the, outside the the In addition to the BMI, DBP, the the rest of indicators the differences were statistically the significance (P <0.05 and P <0.01). (2) the the impact of of the the the drug treatment of on the the the blood sugar and blood lipids. 112 cases of in patients with treatment of three months reexamination, the there are obvious decline in (P <0.05 and P <0.01). In the than that before treatment of the the Astragalus the group and rhubarb of group FBS, TC, TG, LDL-C, the of HDL-C and the LPa Compared with the control group after treatment, the average Astragalus group and rhubarb group TC water significantly decreased (P <0.01), and rhubarb group level significantly lower than the the Astragalus group (P <0.05); compared with the control group, rhubarb group TG the the level of significantly reduce the (P <0.01)., the Astragalus group, despite the reduce the, and but of did not reach statistical significance; compared to the with the control group, the the the LDL-C of of the Astragalus group and the LPa the level of significantly reduce the the (P <0.01), the rhubarb group although the will decline due to shorter, but did not reach statistical significance, as and the as The Astragalus group the level of was significantly lower than the rhubarb group (P <0.05); the three groups of interglacial HDL-C levels None significantly differences in. (3) comparison of serum inflammatory factors. Compared to the with the control group, the the hs-CRP water of the the Astragalus the group and rhubarb of group an average of significantly reduce the (P all <0.01)., And the the level of Rhubarb group was significantly lower than the Astragalus group (P <0.05); with the the compared to the control group, the Astragalus the group and rhubarb of the average Group IL-6 water significantly a (P are <0.01) reduction in, and the the level of Rhubarb group significantly forward to lower than the Astragalus group (P <0.05); compared to the with the control group, astragali group and rhubarb group of TNF-α water an average of significantly forward to decreased (P <0.05 and P <0.01), and the level of rhubarb group was significantly lower than that of the the Astragalus group (P <0.05); the rhubarb group TLR4 levels were significantly lower (P <0.05), despite the reduced Astragalus group compared with the control group, but not reached statistical significance. (4) in each group the levels of plasma NO and the the comparison of of ET-1 concentration of. There are obvious decline in (P <0.05) in the Astragalus group and the the NO of the Rhubarb group and before the ET-1 compared with the treatment of. With the the compared to the control group, the the the the of NO of the astragali group and the ET-1 levels significantly reduce the (P <0.01)., The rhubarb group, despite the reduce the, and but of did not reach statistical significance, and the the level of of the astragali group significantly lower than the the rhubarb group (P <0.05 ). (5) two groups of of the different Age segment in patients with coronary heart disease serum to the the comparison of of the the inflammatory factor the concentration of. After the Compare the were statistically significance of of the two groups of medication before and after the (P <0.01), of hs-of the after the the of which in the young and middle-aged group, rhubarb group the treatment of CRP, IL-6, the of TNF-α and TLR-4 The content of obvious decline in, the treatment of with the Astragalus group There was statistically significant (P <0.05). In the the senile group, astragali group hs-CRP, IL-6 is evident decline in and the the a larger the yellow group of the TNF-α content (P <0.05), while the the TLR4 of the content of the difference was not statistically significance (P> 0.05). (6) the comparison of two different course of coronary heart disease in patients with inflammatory factor concentration. The the Compare the were statistically significance of before and after the the in the two groups of medication (P <0.01 and P <0.05, respectively), the of which after the the the treatment of of in the short course of the disease group, rhubarb group hs-CRP, IL-6, the of TNF-α and content of TLR-4 obvious decline in, with the after the the the treatment of of the Astragalus group compare have the statistically significance (P <0.01 and P <0.05). In the the group of the long course of the disease, Astragalus group hs-CRP, IL-6, and TNF-α content the larger the yellow group decline in obvious (P <0.05), while the the TLR4 of the content of the difference was not statistically significance (P> 0.05). Conclusion (1) The of Astragalus Membranaceus and rhubarb able to play a the the role of of anti-inflammatory and anti-artery porridge kind of to hardening of the. Through the reduce the the the serum lipids and serum inflammation factor the level of, to improve the endothelial function, and, etc. on pathways (2) The bitter cold medicine atherosclerotic inflammatory cytokines stronger than sweet warm temperature and tonic. Of the anti-inflammatory the effect of of the rhubarb obvious is superior to the Astragalus, while the the the the role of of the the the the of the lowering blood pressure and protection of endothelial of of the Astragalus is stronger than the for the rhubarb. (3) better than Astragalus, Astragalus stronger than that of the elderly inflammatory factors rhubarb rhubarb inhibition of young and middle-aged patients with inflammatory factors. (4) than Astragalus, Astragalus inhibition of inflammatory factors in patients with long course better than rhubarb rhubarb on the inhibition of the short course of the disease in patients with inflammatory factors. (5) throughout the atherosclerotic inflammation in the evolution of Chinese medicine is not equivalent to toxic heat, but the the organism long-term chronic loss, imbalance of yin and yang of systemic reactions.
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